GROWTH CONE GUIDANCE IN INSECTS - FASCICLIN-II IS A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY
GROWTH CONE GUIDANCE IN INSECTS - FASCICLIN-II IS A MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY
复制标题
DOI：
10.1126/science.3187519
复制
发表时间：
1988-11-04
期刊：
影响因子：
56.9
通讯作者：
GOODMAN, CS
中科院分区：
文献类型：
--
作者：
HARRELSON, AL;GOODMAN, CS
引导神经元生长锥朝向其目标的细胞线索在昆虫和脊椎动物等多种生物体中高度保守。这里提供的证据表明这些事件背后的分子机制可能同样保守。本文描述了成束蛋白 II 的结构和功能，成束蛋白 II 是一种在蚱蜢胚胎中成束轴突子集上表达的糖蛋白。抗体扰动实验表明，成束蛋白 II 的功能是介导一种形式的神经元识别：选择性成束作用。 Fasciclin II 是免疫球蛋白基因超家族的成员，在结构和功能上与神经细胞粘附分子 N-CAM 和其他几种脊椎动物细胞粘附分子同源。
The cellular cues that guide neuronal growth cones toward their targets are highly conserved in such diverse organisms as insects and vertebrates. Evidence presented here suggests that the molecular mechanisms underlying these events may be equally conserved. This article describes the structure and function of fasciclin II, a glycoprotein expressed on a subset of fasciculating axons in the grasshopper embryo. Antibody perturbation experiments suggest that fasciclin II functions in mediating one form of neuronal recognition: selective fasciculation. Fasciclin II is a member of the immunoglobulin gene superfamily and is homologous in structure and function to the neural cell adhesion molecule N-CAM and to several other vertebrate cell adhesion molecules.