Urinary trypsin inhibitor may have a protective effect on endothelial cells in preeclampsia
Urinary trypsin inhibitor may have a protective effect on endothelial cells in preeclampsia
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尿胰蛋白酶抑制剂可能对先兆子痫的内皮细胞具有保护作用
DOI：
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发表时间：
1994
影响因子：
4.3
通讯作者：
T. Terao
中科院分区：
文献类型：
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作者：
E. Maradny;N. Kanayama;A. Halim;K. Maehara;T. Terao
尿胰蛋白酶抑制剂是一种糖蛋白，对多种酶，尤其是中性粒细胞弹性蛋白酶有抑制作用。本文测定了20例子痫前期患者血清（母儿）、尿液及羊水中尿胰蛋白酶抑制剂的浓度，并与正常妊娠组进行比较。与正常妊娠相比，先兆子痫患者的母亲和胎儿血清中尿胰蛋白酶抑制剂水平显著升高（p < 0.0001），同一患者的尿液和羊水中也是如此。与正常孕妇血清相比，先兆子痫血清显著增加了人脐静脉内皮细胞培养物中钙螯合剂（fura-2）的相对荧光释放（p < 0.03）。尿胰蛋白酶抑制剂与培养物孵育后，观察到fura-2释放显著减少（p < 0.03）。
Urinary trypsin inhibitor is a glycoprotein which has an inhibitory effect on many enzymes, especially neutrophil elastase. The concentration of urinary trypsin inhibitor in serum (maternal and fetal), urine and amniotic fluid was measured in 20 cases of preeclampsia and compared with levels in normal pregnancy. Urinary trypsin inhibitor levels were significantly increased in the maternal and fetal serum of preeclamptic patients compared to normal pregnancy (p < 0.0001), as well as in urine and amniotic fluid of the same patients. Relative fluorescence release of a calcium chelating agent (fura‐2) from human umbilical vein endothelial cell cultures was significantly increased by preeclamptic serum compared to serum of normal pregnant women (p < 0.03). After incubation of urinary trypsin inhibitor with the cultures, significant decrease of fura‐2 release was observed (p < 0.03).
DOI：
10.1016/0002-9378(89)90665-0
发表时间：
1989-11-01
影响因子：
9.8
作者：
ROBERTS, JM;TAYLOR, RN;MCLAUGHLIN, MK
通讯作者：
MCLAUGHLIN, MK
DOI：
10.1111/j.0954-6820.1987.tb09912.x
发表时间：
2009-04
期刊：
Acta medica Scandinavica. Supplementum
影响因子：
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作者：
J. Harlan
通讯作者：
J. Harlan