Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria.
Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria.
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自体生长因子在培养的胎鼠颅骨中刺激 DNA 和胶原蛋白的合成。
DOI：
10.1126/science.7434011
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Raisz,LG
中科院分区：
文献类型：
--
作者：
Canalis,E;Peck,WA;Raisz,LG
从19至21天的胎鼠头骨制备的器官或细胞培养物中提取的条件培养基刺激了同一组织的器官培养物中[3H]脯氨酸与胶原蛋白和[3H]胸苷与DNA的结合。皮质醇的加入增强了胶原蛋白的作用，但对DNA合成没有影响。这些影响似乎是由于不可透析和热稳定的生长因子。
Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H]proline into collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.