Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones
Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones
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DOI：
10.1128/aac.01095-07
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发表时间：
2008-02-01
影响因子：
4.9
通讯作者：
Aubry, Alexandra
中科院分区：
文献类型：
--
作者：
Matrat, Stephanie;Cambau, Emmanuelle;Aubry, Alexandra
通过抑制超螺旋和促进DNA切割，研究了麻风分枝杆菌DNA旋转酶携带的各种突变（先前在临床菌株中描述）对喹诺酮类药物的敏感性。我们证明了导致G89C或A91V的gyrA突变赋予氟喹诺酮耐药，而导致D205N的gyrB突变则不赋予氟喹诺酮耐药。
Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.