Comparison of pallidal and subthalamic stimulation on force control in patient's with Parkinson's disease
Comparison of pallidal and subthalamic stimulation on force control in patient's with Parkinson's disease
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DOI：
10.1123/mcj.8.4.484
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发表时间：
2004-10-01
期刊：
影响因子：
1.1
通讯作者：
Vitek, JL
中科院分区：
文献类型：
--
作者：
Alberts, JL;Elder, CM;Vitek, JL
本研究的目的是确定单侧脑深部刺激(DBS)对帕金森病(PD)患者握力控制和协调的影响。10例进展期PD患者单侧苍白球(GPI)或丘脑底核(STN)DBS患者(每组各5例)进行功能性双手灵巧操作。实验是在DBS“开”和“关”的“关”药物状态下进行的。DBS的结果是：(A)显著的临床改善，(B)更大的双侧肢体最大握力，(C)减少运动时间，(D)双侧握力耦合。GPI组和STN组之间在任何临床或运动学指标上都没有显著差异。GPI和STN的DBS有助于改善晚期PD患者的运动功能。DBS期间力量计时规范的改进可能允许PD患者采用前馈力量控制方法。
The aim of this study was to determine the effects of unilateral deep brain stimulation (DBS) on the control and coordination of grasping forces produced by Parkinson's disease (PD) patients. Ten advanced PD patients with unilateral DBS in the globus pallidus (GPi) or the subthalamic nucleus (STN) (5 patients in each group) performed a functional bimanual dexterous manipulation task. Experiments were performed in the "Off" medication state with DBS "On" and "Off." DBS resulted in (a) significant clinical improvements, (b) greater maximum grip force for both limbs, (c) reduced movement time, and (d) bilateral coupling of grasping forces. There were no significant differences between the GPi and STN groups for any clinical or kinematic measures. DBS of the GPi and STN leads to an improvement-in the motor functioning of advanced PD patients. Improvement in force-timing specification during DBS might allow PD patients to employ a feedforward method of force control.