Characterization of plasma-induced cell membrane permeabilization: focus on OH radical distribution
Characterization of plasma-induced cell membrane permeabilization: focus on OH radical distribution
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DOI：
10.1088/0022-3727/49/33/334002
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发表时间：
2016-08-24
影响因子：
3.4
通讯作者：
Kaneko, Toshiro
中科院分区：
文献类型：
--
作者：
Sasaki, Shota;Honda, Ryosuke;Kaneko, Toshiro
非平衡大气压等离子体（APP）在医学上用于等离子体诱导的细胞透化。然而，等离子体照射如何特异性地触发透化作用仍不清楚。在试图确定的主导因素（S），等离子体产生的活性物种的分布进行了调查，主要集中在OH自由基。较强的等离子体放电，在气相中产生更多的OH自由基，也产生更多的OH自由基在液相中（OHaq），提高细胞膜的渗透性。此外，随着溶液厚度的增加，等离子体辐射诱导的细胞膜通透性增强显著降低（
Non-equilibrium atmospheric-pressure plasma (APP) is used medically for plasma-induced cell permeabilization. However, how plasma irradiation specifically triggers permeabilization remains unclear. In an attempt to identify the dominant factor(s), the distribution of plasma-produced reactive species was investigated, primarily focusing on OH radicals. A stronger plasma discharge, which produced more OH radicals in the gas phase, also produced more OH radicals in the liquid phase (OHaq), enhancing the cell membrane permeability. In addition, plasma irradiation-induced enhancement of cell membrane permeability decreased markedly with increased solution thickness (