A discrete cell model with adaptive signalling for aggregation of Dictyostelium discoideum
A discrete cell model with adaptive signalling for aggregation of Dictyostelium discoideum
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DOI：
10.1098/rstb.1997.0029
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发表时间：
1997-03-29
影响因子：
6.3
通讯作者：
Othmer, HG
中科院分区：
文献类型：
--
作者：
Dallon, JC;Othmer, HG
盘基网柄藻（Dd）是一个广泛研究的模型系统，从中可以获得对细胞运动、趋化、聚集和模式形成的基本见解。在该系统中，聚集由分散的阿米巴对化学引诱物cAMP的行波的趋化反应引起。我们已经开发了一个模型，其中细胞被视为离散点在一个连续的领域的化学引诱物，和转导的细胞外cAMP信号到细胞内的信号是基于G蛋白模型开发的唐和Othmer。该模型再现了一些实验观察，并提供了进一步的洞察聚集过程。我们调查不同的规则，细胞运动，影响流形成的因素，在选择的运动方向的噪声聚集的效果，以及当螺旋波的化学引诱物和细胞密度可能发生。我们的研究结果提供了新的见解的起源螺旋波，并建议流是由于有限振幅的不稳定性。
Dictyostelium discoideum (Dd) is a widely studied model system from which fundamental insights into cell movement, chemotaxis, aggregation and pattern formation can be gained. In this system aggregation results from the chemotactic response by dispersed amoebae to a travelling wave of the chemoattractant cAMP. We have developed a model in which the cells are treated as discrete points in a continuum field of the chemoattractant, and transduction of the extracellular cAMP signal into the intracellular signal is based on the G protein model developed by Tang & Othmer. The model reproduces a number of experimental observations and gives further insight into the aggregation process. We investigate different rules for cell movement, the factors that influence stream formation, the effect on aggregation of noise in the choice of the direction of movement, and when spiral waves of chemoattractant and cell density are likely to occur. Our results give new insight into the origin of spiral waves and suggest that streaming is due to a finite amplitude instability.