Risk Factors Associated with Subclinical Human Infection with Avian Influenza A (H5N1) Virus-Cambodia, 2006
Risk Factors Associated with Subclinical Human Infection with Avian Influenza A (H5N1) Virus-Cambodia, 2006
复制标题
DOI：
10.1086/599208
复制
发表时间：
2009-06-15
影响因子：
6.4
通讯作者：
Katz, Jacqueline M.
中科院分区：
文献类型：
--
作者：
Vong, Sirenda;Ly, Sowath;Katz, Jacqueline M.
背景我们在柬埔寨的2个村庄进行了调查，那里发生了人和家禽之间的H5 N1流感疫情，以确定H5 N1病毒传播的频率和危险因素。在2006年5月期间，类似于在家禽中爆发H5 N1流感后7周，对居住在两名H5 N1流感患者家庭附近的村民进行了访谈，了解可能的H5 N1暴露情况，并采集了血液样本，通过微量中和试验进行H5 N1血清学检测。血清阳性结果定义为流感H5 N1中和抗体滴度>= 1：80，并通过蛋白质印迹试验确认。进行了一项病例对照研究，以确定H5 N1流感病毒感染的危险因素。对照受试者，谁有血清阴性的测试结果，与H5 N1血清阳性的人匹配的村庄居住，家庭与H5 N1流感感染的家禽群，性别和年龄。674名村民中有7名（1.0%）H5 N1流感抗体检测呈阳性，未报告严重疾病; 6名（85.7%）为男性。7名H5 N1血清反应呈阳性者，均为老年人，
Background. We conducted investigations in 2 villages in Cambodia where outbreaks of influenza H5N1 occurred among humans and poultry to determine the frequency of and risk factors for H5N1 virus transmission.Methods. During May 2006, similar to 7 weeks after outbreaks of influenza H5N1 among poultry occurred, villagers living near households of 2 patients with influenza H5N1 were interviewed about potential H5N1 exposures and had blood samples obtained for H5N1 serological testing by microneutralization assay. A seropositive result was defined as an influenza H5N1 neutralizing antibody titer of >= 1:80, with confirmation by Western blot assay. A case-control study was conducted to identify risk factors for influenza H5N1 virus infection. Control subjects, who had seronegative results of tests, were matched with H5N1-seropositive persons by village residence, households with an influenza H5N1-infected poultry flock, sex, and age.Results. Seven (1.0%) of 674 villagers tested seropositive for influenza H5N1 antibodies and did not report severe illness; 6 (85.7%) were male. The 7 H5N1-seropositive persons, all of whom were aged