A NOVEL MYELIN-ASSOCIATED GLYCOPROTEIN DEFINED BY A MOUSE MONOCLONAL-ANTIBODY
A NOVEL MYELIN-ASSOCIATED GLYCOPROTEIN DEFINED BY A MOUSE MONOCLONAL-ANTIBODY
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DOI：
10.1016/0165-5728(84)90064-x
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
WOODHAMS, PL
中科院分区：
文献类型：
--
作者：
LINNINGTON, C;WEBB, M;WOODHAMS, PL
A novel myelin antign was defined by a mouse monoclonal antibody (8-18C5) raised against rat cerebellar glycoproteins. By immunohistochemistry, the antigen was detected in white matter tracts of the CNS, but was absent from peripheral myelin. Western blotting followed by immunostaining revealed that the antigen was a glycoprotein of MW 51,000 daltons which was degraded on storage to cross-reacting products of 20-26,000 daltons. Antigen was detected in central but not peripheral nervous system samples. Products of identical MW were obtained by affinity chromatography of iodinated cerebellar glycoproteins on a column of immobilized 8-18C5.
