Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases
Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases
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DOI：
10.1007/s00280-009-1087-5
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发表时间：
2010-04-01
影响因子：
3
通讯作者：
Danenberg, Peter V.
中科院分区：
文献类型：
--
作者：
Kuramochi, Hidekazu;Hayashi, Kazuhiko;Danenberg, Peter V.
据报道，EGFR mRNA的高表达水平与表皮生长因子受体（EGFR）靶向药物的更高反应概率相关。我们的目的是确定原发性结直肠癌（CRC）的EGFR基因表达水平与肝转移相关。分析了31对原发性结直肠癌和相应的肝转移。采用实时荧光定量RT-PCR检测EGFR基因表达水平，原发癌与相应肝转移癌EGFR mRNA中位表达水平差异无统计学意义（P = 0.99）。EGFR mRNA在大肠癌原发灶和相应肝转移灶中的表达存在显著相关性（r（s）= 0.78，P < 0.0001），通过检测大肠癌原发灶中EGFR mRNA的表达水平，可以较好地预测肝转移灶中EGFR mRNA的表达水平。
High expression levels of EGFR mRNA are reported to be associated with a higher response probability in epidermal growth factor receptor (EGFR) targeted drugs. Our aim was to determine how EGFR gene expression levels in primary colorectal cancer (CRC) were related to those in liver metastases.31 pairs of primary CRC and corresponding liver metastases were analyzed. Gene expression level was measured using real-time RT-PCR.No significant difference was observed between median mRNA expression levels of EGFR in primary cancer and those in corresponding liver metastases (P = 0.99). When matched tissue sets were compared on an individual basis, there was a significant correlation for EGFR mRNA expression between primary cancer and corresponding liver metastases (r (s) = 0.78, P < 0.0001).A good prediction of EGFR mRNA levels in liver metastases can be obtained by measuring those in the primary CRC.