PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo
PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo
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DOI：
10.2217/imt-2017-0046
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发表时间：
2017-09-01
期刊：
影响因子：
2.8
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
--
作者：
Kuroda, Hiromasa;Mabuchi, Seiji;Kimura, Tadashi
评估PM01183清除髓源性抑制细胞（myeloid-derived suppressor cells, MDSCs）的能力。材料与方法：体外和体内观察PM01183对MDSCs、NK细胞和CD8(+) T细胞的影响。PM01183消耗MDSCs的机制也被研究。结果：PM01183通过诱导细胞凋亡减少MDSCs的数量，通过抑制精氨酸酶-1的产生减轻mdsc介导的CD8(+) T细胞的抑制，而对CD8+ T细胞和NK细胞没有明显影响。PM01183对MDSC的抑制作用是通过抑制STAT3磷酸化介导的。PM01183对MDSCs的抑制作用大于现有的抗癌药物。结论：PM01183对MDSCs具有较强的抑制作用。
To evaluate the ability of PM01183 to eliminate myeloid-derived suppressor cells (MDSCs). Materials & methods: The effect of PM01183 on MDSCs, NK cells and CD8(+) T cells was examined in vitro and in vivo. The mechanism by which PM01183 depletes MDSCs was also investigated. Results: PM01183 reduced the number of MDSCs by inducing apoptosis and attenuated the MDSC-mediated suppression of CD8(+) T cells by inhibiting arginase-1 production, whereas no significant effect on CD8+ T or NK cells was noted. The inhibitory effect of PM01183 on MDSC was mediated by the attenuation of STAT3 phosphorylation. The inhibitory effect of PM01183 on MDSCs was greater than those of existing anticancer agents. Conclusion: PM01183 exhibits strong inhibitory effects on MDSCs.