Vagal tone as an indicator of treatment response in major depression
Vagal tone as an indicator of treatment response in major depression
复制标题
DOI：
10.1111/1469-8986.3960861
复制
发表时间：
2002-11-01
期刊：
影响因子：
3.7
通讯作者：
Allen, JJB
中科院分区：
文献类型：
--
作者：
Chambers, AS;Allen, JJB
在重度抑郁症中，迷走神经张力的增加与使用药物和认知行为治疗的成功有关。但不使用电休克疗法。本研究调查了迷走神经张力的增加是否与非药物治疗的良好治疗反应有关。在基线和随后的治疗中，16名受试者接受了汉密尔顿抑郁量表(HRSD)的评估，随后进行了心电图记录。治疗前后迷走神经张力变化不大的患者HRSD评分下降幅度最小(-4.8)，迷走神经张力变化较大的患者HRSD评分下降幅度较大(-14.8)。因此，迷走神经张力的变化与抑郁症的良好治疗反应有关，并不代表抗胆碱能药理效应，未来操纵迷走神经张力的工作可能有助于区分迷走神经张力和抑郁症的因果关系。
Increased vagal tone has been associated with treatment Success using pharmacological agents and cognitive-behavioral treatment in major depression. but not using electroconvulsive therapy. The present study investigated whether increases in vagal tone would be associated with favorable treatment response with nonpharmacological treatment. At baseline and follows in,, treatment, 16 subjects were administered the Hamilton Rating Scale for Depression (HRSD) followed by electrocardiographic recording. Those with little change in vagal tone from before to after treatment showed minimal reduction in HRSD score (-4.8): those with larger vagal tone change showed a large decrease in HRSD score (-14.8). Changes in vagal tone are thus related to favorable treatment response in depression, and do not represent anticholinergic pharmacological effects, Future work manipulating vagal tone might prove informative in leasing apart the causal role of vagal tone and depression.