Left Ventricular Systolic and Diastolic Function in Normotensive Type 2 Diabetic Patients With or Without Autonomic Neuropathy: A Radionuclide Ventriculography Study
Left Ventricular Systolic and Diastolic Function in Normotensive Type 2 Diabetic Patients With or Without Autonomic Neuropathy: A Radionuclide Ventriculography Study
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DOI：
10.1177/0003319713510966
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发表时间：
2014-11-01
期刊：
影响因子：
2.8
通讯作者：
Athyros, Vasilios
中科院分区：
文献类型：
--
作者：
Didangelos, Triantafyllos P.;Arsos, Georgios;Athyros, Vasilios
对59例无冠状动脉病变(CAD)和高血压的2型糖尿病(T2 DM)患者的左心功能与糖尿病自主神经病变(DAN)的关系进行了研究。糖尿病自主神经病变是通过-gt；=2个异常的自主神经功能测试确定的。静息核素心动图评价左心室收缩和舒张期功能。与非DAN患者(n=24)相比，DAN(n=35)患者调整后的心房对心室充盈的贡献增加(A/V%，30.1%+/-8.2%vs 26.5%+5.1%；P=.031)，提示存在舒张期功能障碍(DD)。两组在峰值充盈率、前1/3充盈分数、射血分数、心输出量和心脏指数方面无差异。糖尿病自主神经病变患者心率增加(77.8+/-6.3次/分vs 69.3+/-3.3次/分；P
We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by >= 2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n = 24), patients with DAN (n = 35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1%+/-8.2% vs 26.5%+ 5.1%; P =.031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8 +/- 6.3 vs 69.3 +/- 3.3 bpm; P