The role of VDAC in cell death: friend or foe?
The role of VDAC in cell death: friend or foe?
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DOI：
10.1016/j.bbamem.2011.10.025
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发表时间：
2012-06
影响因子：
3.4
通讯作者：
Baines, Christopher P.
中科院分区：
文献类型：
--
作者：
McCommis, Kyle S.;Baines, Christopher P.
由于电压依赖性阴离子通道（VDAC）形成线粒体和细胞质之间的界面，其在代谢中的重要性已被充分理解。然而，关于VDAC在细胞死亡中的作用的研究是一个快速发展的领域，不幸的是有许多令人困惑和矛盾的结果。VDAC在外线粒体膜透化中起作用的事实是不可否认的，然而，这背后的机制仍然知之甚少。在这篇综述中，我们将总结显示VDAC在细胞死亡中发挥作用的证据的研究。开始，我们将讨论的证据和反对VDAC参与线粒体通透性转换（MPT），并试图澄清VDAC是不是一个重要组成部分的MPT孔（MPTP）。接下来，我们将评估关于VDAC在细胞死亡中的剩余文献，其可分为三种模型：通过VDAC逃逸的促凋亡剂、VDAC同源或异源寡聚化或通过未知途径导致线粒体外膜透化的VDAC闭合。然后，我们将讨论与诱导/保护细胞死亡相关的VDAC活性调节剂的不断增长的列表。
As the voltage-dependent anion channel (VDAC) forms the interface between mitochondria and the cytosol, its importance in metabolism is well understood. However, research on VDAC’s role in cell death is a rapidly growing field, unfortunately with much confusing and contradictory results. The fact that VDAC plays a role in outer mitochondrial membrane permeabilization is undeniable, however, the mechanisms behind this remain very poorly understood. In this review, we will summarize the studies that show evidence of VDAC playing a role in cell death. To begin, we will discuss the evidence for and against VDAC’s involvement in mitochondrial permeability transition (MPT) and attempt to clarify that VDAC is not an essential component of the MPT pore (MPTP). Next, we will evaluate the remaining literature on VDAC in cell death which can be divided into three models: proapoptotic agents escaping through VDAC, VDAC homo- or hetero-oligomerization, or VDAC closure resulting in outer mitochondrial membrane permeabilization through an unknown pathway. We will then discuss the growing list of modulators of VDAC activity that have been associated with induction/protection against cell death.
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影响因子：
4.8
作者：
Carré, M;André, N;Braguer, D
通讯作者：
Braguer, D
电压依赖性阴离子通道VDAC1在多谷氨酸介导的神经元细胞死亡中的作用。
影响因子：
3.7
作者：
Ghosh T;Pandey N;Maitra A;Brahmachari SK;Pillai B
通讯作者：
Pillai B
影响因子：
56.9
作者：
Antonsson, B;Conti, F;Martinou, JC
通讯作者：
Martinou, JC
影响因子：
5.3
作者：
Eskes, R;Desagher, S;Martinou, JC
通讯作者：
Martinou, JC
影响因子：
56.9
作者：
Cheng, EHY;Sheiko, TV;Korsmeyer, SJ
通讯作者：
Korsmeyer, SJ