The hormonal regulation of cutaneous wound healing
The hormonal regulation of cutaneous wound healing
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DOI：
10.1016/j.clindermatol.2006.09.012
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Ashcroft, Gillian S.
中科院分区：
文献类型：
--
作者：
Gilliver, Stephen C.;Ashworth, Jason J.;Ashcroft, Gillian S.
老年人伤口愈合受损的状况与高发病率和死亡率有关，并给世界卫生服务带来重大的财政负担。最近一系列研究的结果突出了性类固醇激素对皮肤修复过程调节的对比贡献。虽然雌激素加速愈合，但“男性”性激素5 α-二氢睾酮和睾酮的作用主要是有害的。因此，作为人类衰老的正常特征，血清雌激素和雄激素水平之间的平衡发生的变化可能对基本的组织修复过程产生重要影响。(C)2007爱思唯尔公司All rights reserved.
Conditions of impaired wound healing in the elderly are associated with substantial morbidity and mortality and impose a significant financial burden upon the world's health services. The findings of a series of recent studies have served to highlight the contrasting contributions made by sex steroid hormones to the regulation of cutaneous repair processes. Although estrogens accelerate healing, the actions of the "male' sex hormones 5 alpha-dihydrotestosterone and testosterone are primarily deleterious. The shift that occurs in the balance between serum estrogen and androgen levels as a normal feature of human aging may therefore have important consequences for fundamental tissue repair processes. (C) 2007 Elsevier Inc. All rights reserved.