pyewacket, a new zebrafish fin pigment pattern mutant.
pyewacket, a new zebrafish fin pigment pattern mutant.
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DOI：
10.1111/j.1600-0749.2006.00311.x
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发表时间：
2006-06
期刊：
影响因子：
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通讯作者：
Eve M. Mellgren;Stephen L. Johnson
中科院分区：
文献类型：
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作者：
Eve M. Mellgren;Stephen L. Johnson
许多破坏斑马鱼胚胎色素模式的突变体已经被分离出来，随后克隆导致这些表型的突变基因有助于我们了解色素细胞的发育。然而，很少有突变体已被确定，具体影响成人色素模式的发展。通过成年色素模式表型的突变体筛选，我们确定了pyewacket（pye），一种新的斑马鱼突变体，其中成年尾鳍色素模式的发育异常。具体来说，pye突变体有鳍黑色素细胞色素图案缺陷和比野生型鳍更少的黄色素细胞。我们将pye映射到一个间隔，其中存在一个单一的基因，即人类基因DHRSX的斑马鱼直系同源物。pye将是一个信息突变体，用于了解黄色素细胞和黑色素细胞如何相互作用形成成年斑马鱼鳍的色素图案。
Many mutants that disrupt zebrafish embryonic pigment pattern have been isolated, and subsequent cloning of the mutated genes causing these phenotypes has contributed to our understanding of pigment cell development. However, few mutants have been identified that specifically affect development of the adult pigment pattern. Through a mutant screen for adult pigment pattern phenotypes, we identified pyewacket (pye), a novel zebrafish mutant in which development of the adult caudal fin pigment pattern is aberrant. Specifically, pye mutants have fin melanocyte pigment pattern defects and fewer xanthophores than wild-type fins. We mapped pye to an interval where a single gene, the zebrafish ortholog of the human gene DHRSX, is present. pye will be an informative mutant for understanding how xanthophores and melanocytes interact to form the pigment pattern of the adult zebrafish fin.