The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?
The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?
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DOI：
10.3389/fgene.2016.00121
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发表时间：
2016
影响因子：
3.7
通讯作者：
Augusto DG
中科院分区：
文献类型：
--
作者：
Augusto DG
杀伤细胞免疫球蛋白样受体（KIR）的多态性与多种疾病有关，包括感染、自身免疫和癌症。KIR分子是在自然杀伤细胞（NK）表面表达的受体家族，是先天免疫对抗微生物和肿瘤细胞的一线防御。关于KIR多态性在肿瘤易感性中的作用，特别是在白血病和淋巴瘤中，一些研究显示了相互矛盾的结果。有趣的是，HLA配体的存在有时与几种类型的癌症密切相关，显然与它们与KIR的相互作用无关。本文简要回顾了罕见的KIR多态性，并批判性地总结了关于KIR变异对癌症易感性的重要性的最新发现。
The polymorphism of killer cell immunoglobulin-like receptors (KIR) has been associated with several diseases, including infection, autoimmunity and cancer. KIR molecules are a family of receptors expressed on the surface of natural killer cells (NK), frontline defense of innate immunity against microorganisms and neoplastic cells. Some studies have shown conflicting results concerning the role that KIR polymorphism plays in tumor susceptibility, particularly in leukemia and lymphoma. Interestingly, the presence of HLA ligands is sometimes strongly associated with several types of cancer and apparently is not related with their interaction with KIR. This manuscript briefly reviews the uncommon polymorphism of KIR and critically summarizes the recent findings with regards of the importance of KIR variation for cancer susceptibility.