Artemis 123: development of a whole-head infant and young child MEG system
Artemis 123: development of a whole-head infant and young child MEG system
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DOI：
10.3389/fnhum.2014.00099
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发表时间：
2014-03-03
影响因子：
2.9
通讯作者：
Edgar, J. Christopher
中科院分区：
文献类型：
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作者：
Roberts, Timothy P. L.;Paulson, Douglas N.;Edgar, J. Christopher
背景：本文描述的设计新的婴幼儿脑磁图(MEG)系统的一个主要动机是，电生理特征(静息活动和诱发反应)可能作为神经发育障碍的生物标志物，而自闭症谱系障碍(ASD)等条件下的神经元异常可能在发育早期被发现。全头部脑磁图系统通常针对成年人进行了优化/调整。由于神经元电流产生的磁场随着距离的增加而减小(2)，婴儿和幼儿的头部较小(因此增加了大脑到传感器的距离)，因此全头成人脑磁图系统不能为较年轻的个体提供最佳的信噪比。这刺激了全头婴幼儿脑磁图系统Artemis 123的开发。方法：除了描述Artemis 123的设计外，本文的重点是使用Artemis 123获取幼儿的听觉诱发脑磁记录和静息状态数据。数据来自一名14个月大的女性、一名18个月大的女性和一名48个月大的男性。结果：对Artemis 123听觉数据的检验具有通用性和重复性，所有受试者均可观察到听觉反应。听觉脑磁图的测量也被发现是可操纵的，表现出对音调频率的敏感性。此外，诱发成分对发育的敏感度似乎是可以预测的，潜伏期随着年龄的增长而减少。对静息状态数据的检查显示出特征的振荡活动。最后，体模数据显示偶极子源可以定位，误差小于0.5 cm。结论：Artemis 123可以有效地记录4岁及以下婴儿的高质量全头脑磁图。未来的工作将包括研究在类似年龄的儿童中获得体感和视觉记录的可行性，以及从更小的婴儿那里获得记录。因此，Artemis 123有望检测此类神经发育障碍的早期诊断特征。
Background: A major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early indevelopment. Whole-head MEG systems are generally optimized/sized for adults. Since magnetic field produced by neuronal currents decreases as a function of distance(2) and infants and young children have smaller head sizes (and thus increased brain-to-sensor distance), whole-head adult MEG systems do not provide optimal signal-to-noise in younger individuals. This spurred development of a whole-head infant and young child MEG system - Artemis 123.Methods: In addition to describing the design of the Artemis 123, the focus of this manuscript is the use of Artemis 123 to obtain auditory evoked neuromagnetic recordings and resting-state data in young children. Data were collected from a 14-month-old female, an 18-month-old female, and a 48-month-old male. Phantom data are also provided to show localization accuracy.Results: Examination of Artemis 123 auditory data showed generalizability and reproducibility, with auditory responses observed in all participants. The auditory MEG measures were also found to be manipulable, exhibiting sensitivity to tone frequency. Furthermore, there appeared to be a predictable sensitivity of evoked components to development, with latencies decreasing with age. Examination of resting-state data showed characteristic oscillatory activity. Finally, phantom data showed that dipole sources could be localized with an error less than 0.5 cm.Conclusions: Artemis 123 allows efficient recording of high-quality whole-head MEG in infants four years and younger. Future work will involve examining the feasibility of obtaining somatosensory and visual recordings in similar-age children as well as obtaining recordings from younger infants. Thus, the Artemis 123 offers the promise of detecting earlier diagnostic signatures in such neurodevelopmental disorders.