The epidermal growth factor receptor pathway in relation to pelvic lymph node metastasis and survival in early-stage cervical cancer
The epidermal growth factor receptor pathway in relation to pelvic lymph node metastasis and survival in early-stage cervical cancer
复制标题
DOI：
10.1016/j.humpath.2010.04.017
复制
发表时间：
2010-12-01
期刊：
影响因子：
3.3
通讯作者：
van der Zee, Ate G. J.
中科院分区：
文献类型：
--
作者：
Eijsink, Jasper J. H.;Noordhuis, Maartje G.;van der Zee, Ate G. J.
本研究的目的是探讨早期宫颈癌组织中表皮生长因子受体(EGFR)的表达与临床行为的关系。对连续336例接受根治性手术的IB-IIA期宫颈癌患者的临床病理和前瞻性随访资料进行分析，其中EGFR、pEGFR、PTEN、PAKT和PERK的表达分别为321%、21%、38 3%、53%和53%。在4 3%的肿瘤标本中，EGFR阳性与宫颈鳞癌有关(优势比[OR]，7 4 1，95%可信区间[CI]，3 38~16 2 3，P<；多因素分析显示，pEGFR表达阴性伴低分化(OR，0 39，95%CI，0 2 0~0 73，P=0 0 4)，PTEN表达阴性(OR，0 5 1，95%CI，0 30~0 90，P=0 19)，仅有盆腔淋巴结转移(危险比，6 11，95%CI，3 46~10 77，P<；PTEN表达缺失与盆腔淋巴结转移有关，提示PTEN是影响盆腔淋巴结转移的肿瘤抑制基因之一。然而，EGFR通路成分的表达似乎并不影响手术治疗的早期宫颈癌的预后。(C)2010 Elsevier Inc.版权所有
The objective of this study is to correlate the expression of epidermal growth factor receptor (EGFR) components with clinical behavior of early-stage cervical cancer Tissue samples of 336 consecutive Federation of International Gynecologists and Obstetricians stage IB-IIA cervical cancer patients all treated primarily by radical surgery were collected Clinicopathologic and follow-up data were prospectively obtained during standard treatment and follow-up As representatives for the EGFR pathway, expression of EGFR, pEGFR, PTEN, pAKT, and pERK was assessed by immunohistochemistry on tissue microarrays Positive immunostaining was observed for EGFR in 32 1%, for pEGFR in 21 0%, for PTEN in 38 3%, for pAKT in 5 3%, and for pERK in 4 3% of tumor samples Positive EGFR immunostaining was associated with squamous cell carcinoma of the cervix (odds ratio [OR], 7 41, 95% confidence interval [CI], 3 38-16 23, P < 001), negative pEGFR immunostaining with poor differentiation (OR, 0 39, 95% CI, 0 20-0 73, P = 004), and negative PTEN immunostaining with metastatic pelvic lymph nodes (OR, 051, 95% CI, 0 30-0 90, P = 019) In multivariate analysis, only pelvic lymph node metastasis (hazard ratio, 6 11, 95% CI, 3 46-10 77, P < 001) and poor differentiation (hazard ratio, 1 91, 95% CI, 1 12-3 26, P = 018) were related to disease-specific survival In early-stage cervical cancer, loss of PTEN expression is associated with pelvic lymph node metastasis, suggesting PTEN to be one of the tumor suppressor genes affecting pelvic lymph node metastasis However, expression of EGFR pathway components does not appear to have prognostic impact in surgically treated early-stage cervical cancer (C) 2010 Elsevier Inc All rights reserved