Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
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DOI：
10.1126/science.abb9263
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发表时间：
2020-07-31
期刊：
影响因子：
56.9
通讯作者：
Chiu, Charles Y.
中科院分区：
文献类型：
--
作者：
Deng, Xianding;Gu, Wei;Chiu, Charles Y.
由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行已在全球蔓延，截至2020年7月17日，加州的病例超过365，000例。我们从2020年1月下旬至3月在北方加州调查了SARS-CoV-2的基因组流行病学，使用了来自9个县和Grand Princess游轮的36名患者的样本。系统发育分析显示，至少有七种不同的SARS-CoV-2谱系神秘地引入加州，包括与华盛顿州相关的流行性WA 1菌株，缺乏主要谱系，社区间传播有限。与两个县的暴发群相关的谱系通过病毒基因组中的单个碱基替换来定义。这些发现支持接触者追踪、社交距离和旅行限制，以遏制SARS-CoV-2在加州和其他州的传播。
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January tomid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.