XG LOCUS - FAILURE TO DETECT INACTIVATION IN FEMALES WITH CHRONIC MYELOCYTIC LEUKAEMIA
XG LOCUS - FAILURE TO DETECT INACTIVATION IN FEMALES WITH CHRONIC MYELOCYTIC LEUKAEMIA
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DOI：
10.1038/226367a0
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发表时间：
1970-01-01
期刊：
影响因子：
64.8
通讯作者：
ZAVALA, C
中科院分区：
文献类型：
--
作者：
FIALKOW, PT;LISKER, R;ZAVALA, C
X染色体失活假说认为，成年雌性哺乳动物的每个体细胞中只有一条X染色体具有遗传活性。胚胎发生早期的初始事件决定了父方或母方X染色体在任何给定细胞中保持活性，这一事件大概是随机的;一旦做出选择，该细胞及其所有后代的选择就固定了1 -4。虽然这种类型的失活已在人类的许多X连锁基因座中得到证实，但还不知道整个X染色体是否失活。
THE inactive-Xhypothesis states that only one of the twoXchromosomes in each somatic cell of adult mammalian females is genetically active. The initial event in early embryogenesis which determines whether the paternal or the maternalXchromosome will remain active in any given cell is presumably random; once made, the choice is fixed for that cell and for all its descendants1–4. Although this type of inactivation has been demonstrated in man for a number ofX-linked loci5, it is not known whether the entireXchromosome is inactivated.