Brain estrogen production and the encoding of recent experience.
Brain estrogen production and the encoding of recent experience.
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DOI：
10.1016/j.cobeha.2015.11.005
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发表时间：
2015-12
影响因子：
5
通讯作者：
Remage-Healey L
中科院分区：
文献类型：
--
作者：
Vahaba DM;Remage-Healey L
脊椎动物的中枢神经系统整合了认知和行为，它也是类固醇激素如雌激素的来源和靶点。最近对学习和记忆背景下大脑雌激素产生的探索揭示了几个共同的主题。首先，在脊椎动物中，合成雌激素的酶在以神经可塑性升高为特征的大脑区域中表达，并且也是最近经验的获取，巩固和检索的组成部分。第二，测量和操纵雌激素显示，最近的感觉经验后的一段时间与空间和声音学习相关的脑回路中的雌激素信号有关。因此，认知回路中的局部脑雌激素产生可能对记忆的获得和/或巩固很重要，并将讨论测试这些想法的新方向。
The vertebrate central nervous system integrates cognition and behavior, and it also acts as both a source and target for steroid hormones like estrogens. Recent exploration of brain estrogen production in the context of learning and memory has revealed several common themes. First, across vertebrates, the enzyme that synthesizes estrogens is expressed in brain regions that are characterized by elevated neural plasticity and is also integral to the acquisition, consolidation, and retrieval of recent experiences. Second, measurement and manipulation of estrogens reveal that the period following recent sensory experience is linked to estrogenic signaling in brain circuits underlying both spatial and vocal learning. Local brain estrogen production within cognitive circuits may therefore be important for the acquisition and/or consolidation of memories, and new directions testing these ideas will be discussed.