Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps
Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps
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DOI：
10.1177/000348940711600111
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发表时间：
2007-01-01
影响因子：
1.4
通讯作者：
Liu, Hui
中科院分区：
文献类型：
--
作者：
Zhai, Lijie;Sun, Yiqing;Liu, Hui
Objectives: We explored a potential association between nasal polyps (NPs) and polymorphism at loci for human leukocyte antigen (HLA) DR and HLA-DQ.Methods: Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and in 81 healthy subjects by use of the polymerase chain reaction-sequence specific primer method.Results: HLA-DR16, HLA-DQ8, and HLA-DQ9 were found to be significantly associated with NPs. HLA-DR16, HLADQ8. and HLA-DQ9 specificities were found at higher frequencies in patients with NPs than in control subjects (5% versus 0.62%, RR = 8.9, p =.03; 10% versus 2.47%, RR = 4.8 1, p =.01- and 20% versus 6.18%. RR = 4.73%, p =.001; respectively). In contrast, HLA-DQ7 was found at lower frequencies in patients with NPs than in controls (10% versus 20.37%, RR = 0.36, p =.04).Conclusions: We conclude that HLA-DR16, HLA-DQ8, and HLA-DQ9 represent potential susceptibility determinants and that HLA-DQ7 might confer resistance in nasal polyps.
