The Role of Regulatory T Cells in the Modulation of Anti-Tumor Immune Response
The Role of Regulatory T Cells in the Modulation of Anti-Tumor Immune Response
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DOI：
10.2298/sarh1304262r
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发表时间：
2013-03-01
影响因子：
0.2
通讯作者：
Arsenijevic, Nebojsa N.
中科院分区：
文献类型：
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作者：
Radosavljevic, Gordana D.;Jovanovic, Ivan P.;Arsenijevic, Nebojsa N.
调节性T细胞（T-reg）是CD4(+)T细胞的一个亚群，其功能是抑制免疫反应。Treg淋巴细胞可分为两个亚群：在胸腺中发育的天然nT（reg）淋巴细胞和源自外周常规T淋巴细胞的诱导iT（reg）淋巴细胞。大多数Treg淋巴细胞表达高水平的白介素-2 （IL-2）受体a链（CD25）和转录因子FoxP3（对iTreg淋巴细胞的发育和抑制活性至关重要）。癌细胞可以通过激活T-reg淋巴细胞间接调节抗肿瘤免疫反应。已有研究表明，肿瘤诱导的Treg淋巴细胞耗竭导致调节功能丧失，可能会增强效应物反应，导致肿瘤排斥反应，而Treg淋巴细胞数量的增加有效地阻止了肿瘤的破坏。nTreg淋巴细胞越来越多地表达CTLA-4和膜结合tgf - β，从而抑制细胞因子的产生和效应淋巴细胞的反应。iT（reg）淋巴细胞分泌免疫抑制因子，如IL-10和tgf - β。Treg淋巴细胞是抗肿瘤免疫的重要障碍之一。
Regulatory T cells (T-reg) represent a subset of CD4(+)T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nT(reg) lymphocytes that are developed in the thymus and inducible iT(reg) lymphocytes, which originate from conventional T lymphocytes on the periphery. The majority of Treg lymphocytes express high levels of interleukin-2 (IL-2) receptor a chain (CD25) and transcription factor FoxP3 (critical for the development and suppressor activity of iTreg lymphocytes). Cancer cells can modulate anti-tumor immune response indirectly, through the activation of T-reg lymphocytes. It has been shown that the loss of regulatory function by depletion of tumor-induced Treg lymphocytes may enhance effectors response, resulting in tumor rejection, while the increased number of Treg lymphocytes effectively prevents tumor destruction. nTreg lymphocytes express increasingly CTLA-4 and membranebound TGF-beta, which inhibits cytokine production and responses of effectors lymphocytes. iT(reg) lymphocytes secrete immunosuppressive cytokines such as IL-10 and TGF-beta. Treg lymphocytes represent one of important obstruction in anti-tumor immunity.