Interferon-γ expression is an independent prognostic factor in ovarian cancer
Interferon-γ expression is an independent prognostic factor in ovarian cancer
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DOI：
10.1016/j.ajog.2004.05.007
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发表时间：
2004-11-01
影响因子：
9.8
通讯作者：
Daxenbichler, G
中科院分区：
文献类型：
--
作者：
Marth, C;Fiegl, H;Daxenbichler, G
背景资料：上皮性卵巢癌的预后通过肿瘤内CD 3（+）T细胞的存在而改善;已知CD 3（+）T细胞产生干扰素-γ。因此，我们推测，干扰素-γ在卵巢癌浸润性T淋巴细胞的表达可能会导致更好的预后。患者和方法：逆转录聚合酶链反应进行测量干扰素-γ和其他相关基因在正常卵巢（n = 19）和卵巢癌标本（n = 99）的表达。患者的中位随访时间为5.8年。结果：干扰素-γ和CD-3的表达在正常和恶性组织中没有显着差异。高水平干扰素-γ表达的患者无进展生存期和总生存期显著延长。低和高干扰素-γ表达患者的中位进展时间分别为10和29个月（P = 0.039）。相应的生存时间分别为29和44个月（P <0.032）。应用多变量考克斯回归分析表明，干扰素-γ表达是一个独立的预后因素，无进展和总survival.Conclusion：干扰素-γ表达升高与改善卵巢癌患者的临床预后相关。(C)2004年爱思唯尔公司All rights reserved.
Background: Epithelial ovarian cancer prognosis is improved by the presence of intratumoral CD3(+) T cells; which are known to produce interferon-gamma. We therefore speculated that interferon-gamma expression in ovarian cancer-infiltrating T-lymphocytes might cause better prognosis.Patients and methods: Reverse transcriptase polymerase chain reaction was performed to measure the expression of interferon-gamma and other related genes in normal ovaries (n = 19) and in ovarian cancer specimens (n = 99). Median follow-up of patients was 5.8 years.Results: Interferon-gamma and CD-3 expression did not significantly differ in normal and malignant tissue. Patients with high levels of interferon-gamma expression had significantly longer progression-free and overall survival. Median time to progression was 10 and 29 months for patients with low and high interferon-gamma expression, respectively (P = .039). Corresponding survival times were 29 and 44 months (P < .032). Application of multivariate Cox regression analysis showed interferon-gamma expression to be an independent prognostic factor for progression-free and overall survival.Conclusion: Elevated interferon-gamma expression correlates with improved clinical outcome in patients with ovarian cancer. (C) 2004 Elsevier Inc. All rights reserved.