Obstructive sleep apnea and cardiovascular disease
Obstructive sleep apnea and cardiovascular disease
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DOI：
10.1016/s0735-1097(03)00184-0
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发表时间：
2003-05-07
影响因子：
24
通讯作者：
Wilcox, I
中科院分区：
文献类型：
--
作者：
Lattimore, JDL;Celermajer, DS;Wilcox, I
阻塞性睡眠呼吸暂停(OSA)是一种常见的疾病，与心血管疾病和中风的风险增加有关。由于OSA与已知的心血管危险因素密切相关，包括肥胖、胰岛素抵抗和血脂异常，OSA是高血压的独立危险因素，也与充血性心力衰竭、肺高压、心律失常和动脉粥样硬化的发病机制有关。肥胖与OSA风险的增加密切相关，减肥可以减轻OSA的严重程度。目前OSA的标准治疗方法-鼻腔持续正压(CPAP)-消除了睡眠期间的呼吸暂停和随之而来的急性血流动力学变化。长期的CPAP治疗研究表明，夜间心脏缺血发作减少，白天血压水平和左心功能改善。尽管有有效的治疗方法，但阻塞性睡眠呼吸暂停综合征仍未得到充分诊断和治疗。缺乏医生意识是造成这种诊断和治疗不足的主要原因之一。(C)2003年，由美国心脏病学会基金会提供。
Obstructive sleep apnea (OSA) is a common disorder associated with an increased risk of cardiovascular disease and stroke. As it is strongly associated with known cardiovascular risk factors, including obesity, insulin resistance, and dyslipidemia, OSA is an independent risk factor for hypertension and has also been implicated in the pathogenesis of congestive cardiac failure, pulmonary hypertension, arrhythmias, and atherosclerosis. Obesity is strongly linked to an increased risk of OSA, and weight loss can reduce the severity of OSA. The current standard treatment for OSA-nasal continuous positive airway pressure (CPAP)- eliminates apnea and the ensuing acute hemodynamic changes during sleep. Long-term CPAP treatment studies have shown a reduction in nocturnal cardiac ischemic episodes and improvements in daytime blood pressure levels and left ventricular function. Despite the availability of effective therapy, OSA remains an underdiagnosed and undertreated condition. A lack of physician awareness is one of the primary reasons for this deficit in diagnosis and treatment. (C) 2003 by the American College of Cardiology Foundation.