Deficient intracortical inhibition in drug-naive children with attention-deficit hyperactivity disorder is enhanced by methylphenidate
Deficient intracortical inhibition in drug-naive children with attention-deficit hyperactivity disorder is enhanced by methylphenidate
复制标题
DOI：
10.1016/s0304-3940(00)00980-0
复制
发表时间：
2000-04-21
影响因子：
2.5
通讯作者：
Rothenberger, A
中科院分区：
文献类型：
--
作者：
Moll, GH;Heinrich, H;Rothenberger, A
在注意力缺陷多动障碍（ADHD）儿童中，运动性多动是一种显著的异常。因为这种症状可能是由于运动控制不足，运动系统的兴奋性在18个药物初治ADHD儿童8-12岁相比，18个年龄匹配的健康儿童使用经颅磁刺激（TMS）的技术。而运动阈值，皮质沉默期，和皮质内的促进两组之间没有差异，ADHD儿童有显着减少皮质内抑制相比，健康对照组。在所有ADHD儿童中，第二次TMS可以在首次摄入10 mg哌甲酯后开始。在这种药物下，可以说皮质内抑制显著增强。这项研究提供了第一个证据，在ADHD儿童的运动皮层内的抑制缺陷和哌甲酯在这个大脑区域的抑制机制的增强。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
In children with attention-deficit hyperactivity disorder (ADHD), motoric hyperactivity is one of the striking abnormalities. Because this symptom might be due to an insufficient motor control, motor system excitability in 18 drug-naive ADHD-children aged 8-12 years was compared to 18 age-matched healthy children using the technique of transcranial magnetic stimulation (TMS). Whereas motor thresholds, cortical silent period, and intracortical facilitation did not differ between the two groups, ADHD-children had significantly reduced intracortical inhibition compared to healthy controls. In all ADHD-children, a second TMS could be started after their first intake of 10 mg methylphenidate. Under this medication, a significant enhancement in intracortical inhibition could be stated. This study provides the first evidence for inhibitory deficits within the motor cortex in ADHD-children and for an enhancement of inhibitory mechanisms in this brain region by methylphenidate. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.