Fast and facile one-step synthesis of monodisperse thermo-responsive core–shell microspheres and applications
Fast and facile one-step synthesis of monodisperse thermo-responsive core–shell microspheres and applications
复制标题
DOI：
10.1039/c5py00889a
复制
发表时间：
2015-09
影响因子：
4.6
通讯作者：
Jianbo Tan;Mingguang Yu;Xin Rao;Jianwen Yang;Z. Zeng
中科院分区：
文献类型：
--
作者：
Jianbo Tan;Mingguang Yu;Xin Rao;Jianwen Yang;Z. Zeng
采用室温光引发RAFT分散聚合法，一步合成了具有温敏性壳层的高度单分散PMMA微球。采用具有不同低临界溶解温度（LCST）的温度响应性大分子RAFT试剂（P（mPEGA-co-MEA）-TTC）作为稳定剂。超过95%的粒子产率在45分钟内实现的UV照射，显示出快速的过程。所得微球在低于LCST的温度下良好分散于水中，并在高于LCST的温度下从水性分散体中沉淀，表现出可逆的热响应性质。通过分批加入单体可以精确控制微球的粒径，并且在反应过程中微球保持了较高的均匀性。通过RAFT大分子链上的羧基基团，热响应性PMMA微球可以有效地与蛋白质结合。以P（mPEGA-co-MEA）-b-PAA稳定的PMMA微球为模板，合成了具有温敏性的PMMA/ZIF-8核壳结构，并对亚甲基蓝表现出良好的吸附性能。
Highly monodisperse PMMA microspheres covered with a thermo-responsive shell were synthesized in a single step by means of photoinitiated RAFT dispersion polymerization at room temperature. Thermo-responsive macro-RAFT agents (P(mPEGA-co-MEA)-TTCs) with different lower critical solution temperatures (LCST) were used as stabilizers in the process. Particle yields of over 95% were achieved within 45 min of UV irradiation, showing a fast process. The microspheres obtained were well-dispersed in water at a temperature below the LCST, and precipitated from the aqueous dispersion at a temperature above the LCST, exhibiting reversible thermo-responsive properties. The particle size can be precisely controlled by adding a monomer to the reaction in batches, and the microspheres maintained their high uniformities during the reaction. The thermo-responsive PMMA microspheres can be effectively conjugated to proteins via the carboxyl groups on the macro-RAFT chains. A thermo-responsive PMMA/ZIF-8 core–shell structure was also synthesized by using P(mPEGA-co-MEA)-b-PAA stabilized PMMA microspheres as the template, and exhibited good adsorption properties for methylene blue.