Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung.
Granulocyte colony-stimulating factor-producing large cell undifferentiated carcinoma of the lung.
复制标题
产生粒细胞集落刺激因子的大细胞未分化肺癌。
作者：
Noriharu Shijubo;Y. Inoue;Michio Hirasawa;Tomofumi Igarashi;Masaki Mori;Akihiro Matsuura;Toshimitsu Uede;Akira Suzuki
我们报告一例产生粒细胞集落刺激因子（G-CSF）的肺癌。一名38岁的日本女性患有左肺大细胞未分化癌，伴有严重的粒细胞增多症，无任何感染证据。从转移性颈部淋巴结中取出标本，并建立肿瘤细胞系。用夹心酶免疫法检测细胞培养上清及患者血清中G-CSF的含量。免疫组化结果显示，抗人G-CSF单克隆抗体4A 6在裸鼠移植瘤细胞胞浆中呈颗粒状染色。
We report a case of granulocyte colony-stimulating factor (G-CSF) producing lung cancer. A 38-year-old Japanese woman had a large cell undifferentiated carcinoma of the left lung with severe granulocytosis without any evidence of infection. A specimen was taken from a metastatic cervical lymph node and a tumor cell line was established. The culture supernatant of the line as well as patient's serum exhibited a high level of G-CSF by sandwich enzyme immunoassay. Immunohistochemical analysis demonstrated that tumor cells from transplanted nude mice were stained granularly in the cytoplasma by anti-human G-CSF monoclonal antibody, 4A6.
人黑色素瘤细胞系产生粒细胞集落刺激因子。
影响因子：
2.6
作者：
Lilly,MB;Devlin,PE;Devlin,JJ;Rado,TA
通讯作者：
Rado,TA
从人胰腺癌 (MIA PaCa-2) 细胞中纯化和表征人集落刺激因子 1。
影响因子：
3.9
作者：
Shieh,JH;Cini,JK;Wu,MC;Yunis,AA
通讯作者：
Yunis,AA