Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells.
Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells.
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DOI：
10.3389/fimmu.2018.00664
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发表时间：
2018
影响因子：
7.3
通讯作者：
Cervi L
中科院分区：
文献类型：
--
作者：
Motran CC;Silvane L;Chiapello LS;Theumer MG;Ambrosio LF;Volpini X;Celias DP;Cervi L
蠕虫在宿主体内的长期存活是宿主和寄生虫之间适应或动态共同进化过程的结果。然而，蠕虫寄生虫的感染引起宿主组织的损伤，产生危险信号的释放，所述危险信号诱导各种细胞的募集，包括先天性免疫细胞如巨噬细胞（Mo）、树突细胞（DC）、嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞。在这种情况下，这些细胞能够分泌可溶性因子，这些可溶性因子协调依赖于这些寄生虫栖息的不同小生境的免疫效应机制。在这里，我们专注于最近的进展，排泄分泌产物（ESP）的知识，从寄生虫识别DC和Mo。吞噬细胞和其他细胞类型如先天性淋巴细胞T细胞2（ILC2），当被ESP激活时，参与复杂的细胞因子网络以产生先天性和适应性Th2应答。在这篇综述中，我们还讨论了先天免疫细胞诱导的寄生虫杀伤机制和组织修复，以确保蠕虫的生存在很长一段时间。
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the release of danger signals that induce the recruitment of various cells, including innate immune cells such as macrophages (Mo), dendritic cells (DCs), eosinophils, basophils, and mast cells. In this scenario, these cells are able to secrete soluble factors, which orchestrate immune effector mechanisms that depend on the different niches these parasites inhabit. Here, we focus on recent advances in the knowledge of excretory-secretory products (ESP), resulting from helminth recognition by DCs and Mo. Phagocytes and other cells types such as innate lymphocyte T cells 2 (ILC2), when activated by ESP, participate in an intricate cytokine network to generate innate and adaptive Th2 responses. In this review, we also discuss the mechanisms of innate immune cell-induced parasite killing and the tissue repair necessary to assure helminth survival over long periods of time.