Studies on convulsive disorders in young children. II. Intermittent phenobarbital prophylaxis and recurrence of febrile convulsions.
Studies on convulsive disorders in young children. II. Intermittent phenobarbital prophylaxis and recurrence of febrile convulsions.
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幼儿惊厥性疾病的研究。
DOI：
10.1016/s0022-3476(71)80431-6
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
J. Yerushalmy
中科院分区：
文献类型：
--
作者：
B. J. Berg;J. Yerushalmy
在一组18700名新生儿期存活下来的儿童中，257名在3岁前出现了最初的抽搐。首次发作后的平均随访时间为3.8年。其中62名儿童的父母被建议在首次惊厥后不久在随后的发热发作期间预防性地使用苯巴比妥；其他父母在最初抽搐后一个月内没有得到这样的建议。有些人在晚些时候得到了这样的建议（98），有些人根本没有得到这样的建议（97）。预防治疗的选择没有系统地完成，而是取决于儿科医生在个案中的判断。研究表明，早期预防性治疗组（惊厥发作后1个月内）在惊厥发作后1年内，尤其是惊厥发作后的前6个月内，第二次惊厥复发的概率显著降低。结果也被制成了一些亚组的表格，比如男孩和女孩，白人和黑人。研究方法是为了解决所有可疑病例，有利于未治疗组。因此，研究结果表明间歇性苯巴比妥预防的益处极小。
In a cohort of 18,700 children who survived the neonatal period, 257 had an initial convulsion before the age of 3 years. The average duration of follow-up observation was 3.8 years after the first seizure. The parents of 62 of these children were advised shortly after the initial convulsion to administer phenobarbital prophylactically during subsequent febrile episodes; the other parents were not given such advice within one month after the initial convulsion. Some were given such advice at a later date (98), others not at all (97). The selection for prophylactic treatment was not done systematically but depended on the judgment of the pediatricians in individual cases. The study showed that the group with early prophylactic treatment (within one month after the initial convulsion) had a significantly smaller probability of recurrence of a second convulsion within the first year, especially within the first 6 months, after the initial convulsion. The results were also tabulated for a number of subgroups, such as boys and girls, white and black. The method of study was such as to resolve all doubtful cases in favor of the nontreated group. The findings, therefore, represent minimal benefit of intermittent phenobarbital prophylaxis.