Movement-Related Neuromagnetic Fields in Preschool Age Children
Movement-Related Neuromagnetic Fields in Preschool Age Children
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DOI：
10.1002/hbm.22518
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发表时间：
2014-09-01
影响因子：
4.8
通讯作者：
Johnson, Blake
中科院分区：
文献类型：
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作者：
Cheyne, Douglas;Jobst, Cecilia;Johnson, Blake
我们使用一个定制的小儿脑磁图系统研究了学龄前儿童与自主运动相关的感觉运动脑活动。在17名健康的右利手受试者（8名女性，年龄3.2-4.8岁）中，使用类似视频游戏的任务来产生自我发起的右手或左手食指运动。我们使用波束形成器源分析和替代MRI空间归一化成功地识别了15/17名儿童的运动相关脑活动的时空模式。对侧感觉运动皮层的准备场开始类似于运动开始前0.5秒（运动场，MF），随后是瞬态运动诱发场（MEFs），类似于成人自主起搏运动期间观察到的，但略有延迟，并与源极性反转。我们还观察到运动时感觉运动皮层中mu（8-12 Hz）和beta（15-30 Hz）振荡的调制，但与成人中观察到的相比，具有不同的时间和更强的频带耦合。在运动开始时检测到成人样高频（70-80 Hz）伽马爆发。所有儿童都表现出右侧上级颞回的激活，这与运动侧无关，这在成人中还没有报道过。这些结果为运动相关脑功能的发展提供了新的见解，对于以前没有数据的年龄组。结果表明，5岁以下的儿童有显着不同的模式的运动相关的大脑活动相比，年龄较大的儿童和成人，并表明显着的成熟变化发生在感觉运动系统之间的学龄前和儿童后期。(C)2014 Wiley Periodicals，Inc.
We examined sensorimotor brain activity associated with voluntary movements in preschool children using a customized pediatric magnetoencephalographic system. A videogame-like task was used to generate self-initiated right or left index finger movements in 17 healthy right-handed subjects (8 females, ages 3.2-4.8 years). We successfully identified spatiotemporal patterns of movement-related brain activity in 15/17 children using beamformer source analysis and surrogate MRI spatial normalization. Readiness fields in the contralateral sensorimotor cortex began similar to 0.5 s prior to movement onset (motor field, MF), followed by transient movement-evoked fields (MEFs), similar to that observed during self-paced movements in adults, but slightly delayed and with inverted source polarities. We also observed modulation of mu (8-12 Hz) and beta (15-30 Hz) oscillations in sensorimotor cortex with movement, but with different timing and a stronger frequency band coupling compared to that observed in adults. Adult-like high-frequency (70-80 Hz) gamma bursts were detected at movement onset. All children showed activation of the right superior temporal gyrus that was independent of the side of movement, a response that has not been reported in adults. These results provide new insights into the development of movement-related brain function, for an age group in which no previous data exist. The results show that children under 5 years of age have markedly different patterns of movement-related brain activity in comparison to older children and adults, and indicate that significant maturational changes occur in the sensorimotor system between the preschool years and later childhood. (C) 2014 Wiley Periodicals, Inc.