Local action of exogenous nitric oxide (NO) on the skin blood flow of rock pigeons (Columba livia) is affected by acclimation and skin site
Local action of exogenous nitric oxide (NO) on the skin blood flow of rock pigeons (Columba livia) is affected by acclimation and skin site
复制标题
外源性一氧化氮 (NO) 对原鸽 (Columba livia) 皮肤血流的局部作用受到驯化和皮肤部位的影响
DOI：
10.1242/jeb.01051
复制
发表时间：
2004
影响因子：
2.8
通讯作者：
A. Pyörnilä
中科院分区：
文献类型：
--
作者：
L. Peltonen;A. Pyörnilä
总结我们研究了两组鸽子背部和腹部非育雏斑皮肤的血流：一组是热适应寒冷（冬季适应，WAC），而另一组是适应中温环境（热非挑战，NOC）。同时用含有硝酸钠和抗坏血酸的凝胶和载体凝胶处理测量部位的两个双侧贴片，以产生一氧化氮（NO）。用激光多普勒测速仪测量血流量。根据相应贴片的基本血流量值计算这些治疗引起的变化。结果表明，在两种驯化状态下，在室温下腹部皮肤贴片的基础血流量高于背部皮肤，但比较显示，WAC鸽的基础皮肤血流量持续较高水平。外源性NO的局部反应是不均匀的两个皮肤面积测量，并记录在NOC鸽子腹部微血管的特定血管舒张作用。腹部血管舒张的WAC鸽子似乎涉及其他机制，以及当地NO依赖的，其中冷诱导血管舒张（CIVD）的作用进行了讨论。有趣的是，背侧皮肤似乎对NO的作用反应较低，与适应状态无关。我们的研究结果表明，适应状态和皮肤部位影响外源性NO对局部皮肤血流量的作用，我们认为，差异反映了适应引起的变化，在皮肤的血管分布和热刺激的敏感性和腹部和背部皮肤的作用是不同的环境变化。
SUMMARY We studied the blood flow over dorsal and abdominal, non-brooding patch skin of two groups of pigeons: one group was thermally acclimated to cold (winter-acclimatized, WAC) while the other group was acclimated to a mesic environment (thermally non-challenged, NOC). Two bilateral patches at the measurement sites were treated simultaneously with a gel containing sodium nitrate and ascorbic acid, to generate nitric oxide (NO), and a vehicle gel. Blood flow was measured by laser Doppler velocimetry. Changes induced by these treatments were calculated against basic blood flow values for the corresponding patch. The results showed that the basic blood flow over the abdominal skin patches at room temperature was higher than over the dorsal skin in both acclimation states, but comparison revealed a sustainably higher level of basic skin blood flow in the WAC pigeons. The local response to exogenous NO was non-uniform over the two skin areas measured, and a specific vasodilatory action on the abdominal microvessels was recorded in the NOC pigeons. Abdominal vasodilatation in the WAC pigeons seemed to involve other mechanisms as well as local NO-dependent ones, among which the role of cold-induced vasodilatation (CIVD) is discussed here. Interestingly, the dorsal skin seemed to be less responsive to the action of NO, irrespective of the acclimation state. Our results show that acclimation state and skin site affect the action of exogenous NO on local skin blood flow, and we suggest that the differences reflect acclimation-induced changes in the vascularity of the skin and in its sensitivity to thermal stimuli and that the roles of the abdominal and dorsal skin are different with respect to environmental changes.