Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli.
Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli.
复制标题
猴子受伤神经的异位兴奋性：对振动刺激的夹带反应。
DOI：
10.1152/jn.1991.65.3.693
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发表时间：
1991
影响因子：
2.5
通讯作者：
Campbell,JN
中科院分区：
文献类型：
--
作者：
Koschorke,GM;Meyer,RA;Tillman,DB;Campbell,JN
1. 在麻醉的猴子身上，研究了来自急性切断的神经或神经瘤的髓鞘纤维对机械刺激的反应。桡骨浅神经或腓肠浅神经被紧密结扎和切断。采用单单元记录技术，立即（急性实验）或2-6周后（慢性实验），记录损伤部位附近振动机械刺激（5-100 Hz， 50-800微米）引起的神经活动。2. 慢性实验中研究的30个髓鞘传入事件对神经损伤部位或附近的振动刺激表现出一种夹带反应（每个刺激周期有一个动作电位）。对于19根光纤，最小夹带幅度被确定为频率的函数（调谐曲线）。对于其他11个，虽然可以估计出它们最敏感的频率范围，但没有获得完整的调谐曲线。传入纤维可以分为三组的基础上他们最敏感的频率范围:1)低频组是最敏感的频率小于或等于5赫兹(n = 7), 2)一个中心频率组是最敏感的一个广泛的频率(例如,20 - 75 Hz, n = 13),和3)高频组是最敏感的频率大于或等于100赫兹(n = 10)。这三种反应类型类似于与不同的低阈值机械感受器（即缓慢适应和快速适应和帕西尼类机械感受器）相关的三种反应类型。（摘要删节250字）
1. The responses to mechanical stimulation of myelinated fibers that originate from an acutely cut nerve or a neuroma were studied in the anesthetized monkey. The superficial radial or sural nerve was tightly ligated and cut. Either immediately (acute experiment) or 2-6 wk later (chronic experiment), single-unit recording techniques were used to record the evoked neural activity after vibratory mechanical stimulation (5-100 Hz; 50-800 microns) near the injury site. 2. The 30 myelinated afferents studied in the chronic experiments displayed an entrained response (1 action potential for each stimulus cycle) to vibratory stimuli applied at or near the nerve injury site. For 19 fibers, the minimum amplitude for entrainment was determined as a function of frequency (tuning curve). For 11 others, complete tuning curves were not obtained, although the frequency range over which they were most sensitive could be estimated. The afferents could be classified into three groups on the basis of the frequency range over which they were most sensitive: 1) a low-frequency group that was most sensitive to frequencies less than or equal to 5 Hz (n = 7), 2) a mid-frequency group that was most sensitive to a broad range of frequencies (i.e., 20-75 Hz, n = 13), and 3) a high-frequency group that was most sensitive to frequencies greater than or equal to 100 Hz (n = 10). These three response classes are similar to the three classes of response associated with the different low-threshold mechanoreceptors (i.e., slowly and rapidly adapting and Pacinian-like mechanoreceptors).(ABSTRACT TRUNCATED AT 250 WORDS)