Physical resilience after a diagnosis of cardiovascular disease among offspring of long-lived siblings.
Physical resilience after a diagnosis of cardiovascular disease among offspring of long-lived siblings.
复制标题
长寿兄弟姐妹的后代诊断出心血管疾病后的身体恢复能力。
DOI：
10.1007/s10433-021-00641-7
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发表时间：
2022
影响因子：
3.8
通讯作者：
Christensen,Kaare
中科院分区：
文献类型：
--
作者：
Galvin,Angéline;Feitosa,Mary;Arbeev,Konstantin;Kuipers,AllisonL;Wojczynski,Mary;Ukrainsteva,Svetlana;Christensen,Kaare
长寿家庭的健康效益代代相传，心血管疾病发病率较低，已被证明是造成这一现象的原因。在目前的研究中，我们调查了与匹配的对照组相比，长寿兄弟姐妹的后代在CVD诊断后是否也有更好的生存率，即，它们是否既强健又有弹性？长寿的兄弟姐妹的后代是从三个全国性的丹麦研究中确定的，并与国家登记册相关联。研究纳入了1996年至2011年间首次诊断为急性心肌梗死、慢性缺血性心脏病、心力衰竭或脑血管疾病的后代，并与丹麦人群中的两名对照在性别、出生和诊断年份以及CVD类型方面进行了匹配。对匹配数据进行分层考克斯比例风险模型，以研究10年总生存率。共纳入402名后代和804名对照：64.2%为男性，诊断时的中位年龄为63.0岁。对于后代和对照组，诊断后10年的总生存率分别为73%和65%。长寿兄弟姐妹的后代有一个显着更好的生存比对照组，这种关联略有减弱后，控制婚姻状况，药物和Charlson Comorbid指数评分同时。这项研究表明，与匹配的人群对照相比，长寿兄弟姐妹的后代不仅显示出较低的CVD发病率，而且在CVD诊断后的生存率也更高。较高的生物弹性似乎是长寿丰富的家庭的普遍标志，这使得他们在研究健康衰老和长寿机制方面具有独特的地位。
Health benefits of longevity-enriched families transmit across generations and a lower incidence of cardiovascular diseases (CVD) have been shown to contribute to this phenomenon. In the current study, we investigated whether the offspring of long-lived siblings also have better survival after a CVD diagnosis compared to matched controls, i.e., are they both robust and resilient? Offspring of long-lived siblings were identified from three nationwide Danish studies and linked to national registers. Offspring with first diagnosis of acute myocardial infarction, chronic ischemic heart disease, heart failure or cerebrovascular disease between 1996 and 2011 were included and matched with two controls from the Danish population on sex, year of birth and diagnosis, and type of CVD. Stratified Cox proportional-hazards models on the matching data were performed to study 10-year overall survival. A total of 402 offspring and 804 controls were included: 64.2% male with a median age at diagnosis of 63.0. For offspring and controls, overall survival was 73% and 65% at 10 years from diagnosis, respectively. Offspring of long-lived siblings had a significantly better survival than controls, and this association was slightly attenuated after controlling for marital status, medication and Charlson Comorbidity Index score simultaneously. This study suggested that offspring of long-lived siblings not only show lower CVD incidence but also a better survival following CVD diagnosis compared to matched population controls. The higher biological resilience appears to be a universal hallmark of longevity-enriched families, which makes them uniquely positioned for studying healthy aging and longevity mechanisms.