Integrins and integrin-associated proteins in the cardiac myocyte.
Integrins and integrin-associated proteins in the cardiac myocyte.
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DOI：
10.1161/circresaha.114.301275
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发表时间：
2014-01-31
影响因子：
20.1
通讯作者：
Ross RS
中科院分区：
文献类型：
--
作者：
Israeli-Rosenberg S;Manso AM;Okada H;Ross RS
整合素是异二聚体跨膜受体，在所有细胞中表达，包括心脏细胞。它们参与多种关键的细胞过程，包括粘附、细胞外基质组织、信号传导、存活和增殖。整合素与收缩的肌肉细胞特别相关，是机械传感器，将机械信息转化为生化信息。虽然心血管临床医生和科学家可能对心血管系统中用于抑制血小板聚集的药物中的整合素有最高的认识，但本文的重点将是整合素在心肌细胞中的具体作用。在对整合素生物学进行一般介绍之后，该手稿将讨论整合素信号传导、机械转导的重要工作，以及从一系列模型生物中获得的关于整合素功能的经验教训。然后我们将详细介绍肌细胞中整合素相关蛋白的研究，整合素如何与离子通道相互作用并介导病毒摄取到细胞中，以及在干细胞生物学中发挥作用。最后，我们将讨论未来的学习方向。
Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers, translating mechanical to biochemical information. While it is likely that cardiovascular clinicians and scientists have highest recognition of integrins in the cardiovascular system from drugs used to inhibit platelet aggregation, the focus of this article will be on the role of integrins specifically in the cardiac myocyte. Following a general introduction to integrin biology, the manuscript will discuss important work on integrin signaling, mechanotransduction, and lessons learned about integrin function from a range of model organisms. Then we will detail work on integrin-related proteins in the myocyte, how integrins may interact with ion channels and mediate viral uptake into cells, and also play a role in stem cell biology. Finally, we will discuss directions for future study.