The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses
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DOI：
10.1126/science.276.5311.412
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发表时间：
1997-04-18
期刊：
影响因子：
56.9
通讯作者：
Rajewsky, K
中科院分区：
文献类型：
--
作者：
Kaisho, T;Schwenk, F;Rajewsky, K
在抗体应答中，B细胞从免疫球蛋白（IG）μ和δ重链（H）的表达转换为其他IG类别（α、γ或δ）的表达，每种类别都具有不同的效应子功能。膜结合形式的α，γ和β，但不是μ和δ，具有高度保守的细胞质尾。不能表达膜γ 1 H链或产生无尾γ 1 H链的突变小鼠不能产生有效的IgG1应答和IgG1记忆。因此，这些功能需要类别转换后的H链膜表达，并且类别转换使B细胞抗原受体具有初始B细胞缺乏的调节性胞质尾。
In antibody responses, B cells switch from the expression of immunoglobulin (Ig) mu and delta heavy (H) chains to that of other Ig classes (alpha, gamma, or epsilon), each with a distinct effector function. Membrane-bound forms of alpha, gamma, and epsilon, but not mu and delta, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane gamma 1 H chains or producing tailless gamma 1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naive B cells lack.