Effects of combined block of alpha(1)-adrenoceptors and NMDA receptors on spatial and passive avoidance behavior in rats
Effects of combined block of alpha(1)-adrenoceptors and NMDA receptors on spatial and passive avoidance behavior in rats
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DOI：
10.1016/0014-2999(95)00842-x
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发表时间：
1996-04-04
影响因子：
5
通讯作者：
Riekkinen, P
中科院分区：
文献类型：
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作者：
Riekkinen, M;Stefanski, R;Riekkinen, P
本研究旨在探讨α(1)-肾上腺素能受体和NMDA受体在调节大鼠空间航行和被动回避行为中的相互作用。预先使用α(1)-肾上腺素能受体拮抗剂哌唑嗪(2 mg/kg，ip)可降低小鼠在水迷宫航行试验中的学习成绩，但对被动回避行为无影响。训练后和测试前注射哌唑嗪对水迷宫和被动回避行为没有影响。训练前给予竞争性((+/-))-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic受体拮抗剂N-甲基-D-天冬氨酸(CPP)，剂量依赖地(3 mg/kg和10 mg/kg)可损害大鼠的被动回避和水迷宫行为。CPP训练后对大鼠水迷宫和被动回避行为无明显影响。训练前联合亚阈值剂量的CPP(1 mg/kg)和哌唑嗪(1 mg/kg)可损害水迷宫行为。训练后或预试后，阈下注射CPP(3 mg/kg)和哌唑嗪(1 mg/kg)对小鼠的水迷宫或被动回避成绩无明显影响。对照实验表明，训练前注射CPP 3 mg/kg或CPP 1 mg/kg+哌唑嗪1 mg/kg对线索导航到清晰可见平台没有影响，但CPP 10 mg/kg显著影响运动能力。这些结果表明，α(1)-肾上腺素能受体和NMDA受体可能协同调节空间航行能力的获得。因此，研究α(1)-肾上腺素能受体和NMDA受体的联合刺激对年龄相关性记忆缺陷的影响将是很有意义的。
The present study was designed to investigate the interactions between alpha(1)-adrenoceptors and NMDA receptors in modulating spatial navigation and passive avoidance behavior in rats. Pretraining treatment with prazosin, an alpha(1)-adrenoceptor antagonist, at 2 mg/kg i.p., impaired acquisition performance in a water maze navigation test and had no effect on passive avoidance behavior. Posttraining and pretest injections of prazosin had no effect on water maze or passive avoidance behavior. Pretraining treatment with ((+/-))-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a competitive NMDA receptor antagonist, dose dependently (3 and 10 mg/kg) impaired passive avoidance and water maze behavior. Posttraining treatment with CPP had no effect on water maze and passive avoidance behavior. A pretraining combination of subthreshold doses of CPP (1 mg/kg) and prazosin (1 mg/kg) impaired water maze behavior. A combination of subthreshold doses of CPP (3 mg/kg) and prazosin (1 mg/kg) injected posttraining or pretest had no marked effect on water maze or passive avoidance performance. A control experiment showed that CPP 3 mg/kg or CPP 1 mg/kg and prazosin 1 mg/kg injected pretraining had no effect on cue navigation to a clearly visible platform, but CPP 10 mg/kg markedly impaired performance. The present results indicate that alpha(1)-adrenoceptors and NMDA receptors may synergistically regulate acquisition of spatial navigation performance. ?Therefore, it would be interesting to study the effects of combined stimulation of alpha(1)-adrenoceptors and NMDA receptors on age-related memory defects.