Increased levels of testosterone have little effect on visual cortex plasticity in the kitten.
Increased levels of testosterone have little effect on visual cortex plasticity in the kitten.
复制标题
睾酮水平的增加对小猫视觉皮层的可塑性几乎没有影响。
DOI：
10.1002/neu.480180203
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Parkinson,D
中科院分区：
文献类型：
--
作者：
Daw,NW;Baysinger,KJ;Parkinson,D
We tested the hypothesis that increased levels of sex steroids preceeding puberty are an important factor in the termination of the critical period for monocular deprivation. Male kittens were injected with Depo‐testosterone in order to elevate plasma testosterone to a higher level than that in normal prepubertal male kittens. Control animals did not receive testosterone injections. All kittens were monocularly deprived for 7–18 days, then cells in the visual cortex were examined electrophysiologically, and an ocular dominance histogram was constructed.Treated animals showed an increase in plasma testosterone (1.82–15.16 ng/mL) when compared with the control animals (0.80 ± 0.25 ng/mL). The fraction of cells driven exclusively by the experienced eye was slightly lower in the treated animals, and there was a slight increase in the dominance of cells by both eyes. However, in both groups of animals, the majority of cells were dominated by the experienced eye, with no significant difference in the weighted parameter used to describe this dominance. In summary, although there is a slight difference between treated and control animals, the results do not support the hypothesis that elevated levels of sex steroids play a crucial role in the termination of the critical period.
