An analysis of volatiles in the headspace of the faeces of neonates
An analysis of volatiles in the headspace of the faeces of neonates
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DOI：
10.1088/1752-7155/2/3/037023
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发表时间：
2008-09-01
影响因子：
3.8
通讯作者：
Smith, S.
中科院分区：
文献类型：
--
作者：
Costello, B. De Lacy;Ewen, R.;Smith, S.
对新生儿粪便的顶空进行气相色谱/质谱（GCMS）分析，以记录新生儿单元中与早产儿相关的挥发物。乙醇、丙酮、2-乙基-1-己醇、3-甲基丁醛、己醛和2，3-丁二酮出现频率最高。然后将分析的挥发物与先前发表的无症状成人粪便挥发物研究进行比较。在新生儿粪便中发现的化合物较少，几乎没有检测到硫化物，而在成人样本中，二硫化碳，二甲基二硫醚和二甲基硫醚无处不在。此外，发现最丰富的15种挥发性化合物中有7种是醛，而相比之下，在成人粪便顶部空间中发现的最丰富的15种化合物中只有2种，乙醛和苯甲醛。与成人粪便相比，新生儿粪便中2-乙基-1-己醇的含量明显更高，这可能反映了对含增塑剂的塑料材料的高暴露。讨论了从新生儿粪便中散发的挥发物分析进行疾病诊断的可能性。
A gas chromatography/mass spectrometry (GCMS) analysis of the headspace from the faeces of neonates was undertaken to record the volatiles associated with preterm babies on a neonatal unit. The compounds ethanol, acetone, 2-ethyl-1-hexanol, 3-methylbutanal, hexanal and 2,3-butanedione occurred with the highest frequency. The volatiles analysed were then compared to a previously published study of the volatiles from asymptomatic adult faeces. Fewer compounds were found in the neonatal faeces and virtually no sulfides were detected, in contrast to the adult samples where carbon disulfide, dimethyl disulfide and dimethyl sulfide were ubiquitous. In addition, 7 of the most abundant 15 volatile compounds were found to be aldehydes, while in contrast only 2, acetaldehyde and benzaldehyde, were present in the most abundant 15 compounds found in the headspace of adult faeces. 2-Ethyl-1-hexanol was considerably more abundant in the neonate stool compared to adult stool, and probably reflects high exposure to plastic materials containing plasticizers. The potential of disease diagnoses from the analysis of volatiles emitted from neonate faeces is discussed.