FRUCTOSE AND GLUCOSE-INGESTION AND MUSCLE GLYCOGEN USE DURING SUBMAXIMAL EXERCISE
FRUCTOSE AND GLUCOSE-INGESTION AND MUSCLE GLYCOGEN USE DURING SUBMAXIMAL EXERCISE
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DOI：
10.1152/jappl.1983.55.6.1767
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
BULLEN, BA
中科院分区：
文献类型：
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作者：
LEVINE, L;EVANS, WJ;BULLEN, BA
对四名男性和四名女性受试者在三次跑步机上以大约75%的最大氧气摄取量跑步时摄取果糖、葡萄糖或水后的底物利用率进行了检测。每次测试之前，都要进行三天的高碳水化合物饮食。这些跑道长30分钟，间隔至少1wk。在摄取300毫升随机分配的75克果糖(F)、75克葡萄糖(G)或对照组(C)后45分钟开始锻炼。在F试验中，通过运动前和运动后活检(腓肠肌)测定的肌糖原消耗显著低于C或G试验(P<0.05)。静脉血样本显示，在G饮料后45分钟内，血糖(P<0.05)和胰岛素(P<0.01)显著升高，随后在运动前15分钟内血糖下降(P<0.05)，C或F试验中没有观察到这种变化。在运动的前5分钟，G组的呼吸交换率高于C或F组(P<0.05)，而C组的呼吸交换率在运动后15分钟低于G或F组(P<0.05)。这些数据表明，在次极量运动30分钟前摄入的果糖可以维持稳定的血糖和胰岛素浓度，这可能导致观察到的肌肉糖原的节省。
Substrate utilization after fructose, glucose, or water ingestion was examined in four male and four female subjects during three treadmill runs at approximately 75% of maximal O2 uptake. Each test was preceded by three days of a carbohydrate-rich diet. The runs were 30 min long and were spaced at least 1 wk apart. Exercise began 45 min after ingestion of 300 ml of randomly assigned 75 g fructose (F), 75 g glucose (G), or control (C). Muscle glycogen depletion determined by pre- and postexercise biopsies (gastrocnemius muscle) was significantly (P less than 0.05) less during the F trial than during C or G. Venous blood samples revealed a significant increase in serum glucose (P less than 0.05) and insulin (P less than 0.01) within 45 min after the G drink, followed by a decrease (P less than 0.05) in serum glucose during the first 15 min of exercise, changes not observed in the C or F trials. Respiratory exchange ratio was higher (P less than 0.05) during the G than C or F trials for the first 5 min of exercise and lower (P less than 0.05) during the C trial compared with G or F for the last 15 min of exercise. These data suggest that fructose ingested before 30 min of submaximal exercise maintains stable blood glucose and insulin concentrations, which may lead to the observed sparing of muscle glycogen.