Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development
Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development
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DOI：
10.1080/10286020.2012.723203
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发表时间：
2013-01-01
影响因子：
1.7
通讯作者：
Zhang, Hai-Yan
中科院分区：
文献类型：
--
作者：
Liu, Hao;Chen, Yong-Feng;Zhang, Hai-Yan
对栀子的植物化学、心血管药理、毒理、副作用及进一步开发前景进行了研究，并对其主要成分西红花苷和环烯醚萜苷进行了研究。大量研究证实，西红花苷和环烯醚萜苷具有抗氧化、抗炎、抗动脉粥样硬化、抗缺血性脑损伤、抗血小板聚集、抗高血糖、抗高脂血症、抗高血压等作用。其中一些可能与GJE促进内皮生长、保护神经元、诱导其分化等药效学作用有关。两者都使GJE有可能很好地预防和治疗血栓栓塞症和心血管疾病。通过我们自己对几种大鼠模型的基础药理研究，发现GJE提取物能显著延长出血时间，抑制血小板聚集和血栓形成。对内皮细胞和内皮祖细胞均有明显的增殖作用。在对GJE治疗上述疾病的机制进行探讨和总结的同时，还对其安全性研究中的遗传毒性和肝毒性问题进行了讨论，为今后的长期用药和临床研究奠定了基础。
The phytochemistry, cardiovascular pharmacology, toxicology, side effect, and further development prospects of Gardenia jasminoides J. Ellis (GJE) and its main constituents crocins and iridoid glycosides were studied. Numerous studies have confirmed that crocins and iridoid glycosides had effects of antioxidation, anti-inflammatory, anti-atherosclerosis, anti-ischemic brain injuries, anti-platelet aggregation, anti-hyperglycemia, anti-hyperlipidemia, anti-hypertension, and so on. Some of them might be related to several attractive pharmacodynamic actions of GJE such as promoting endothelium growth, protecting neurons, and inducing their differentiation. Both of them make it possible for GJE to prevent and cure thromboembolism and cardiovascular diseases well. From our own basic pharmacological research of GJE extract on several rat models, it has been known that GJE extract markedly prolonged bleeding time and inhibited platelet aggregation and thrombosis. It has significant proliferation effect on both endothelial cells and endothelial progenitor cells as well. As the mechanisms of GJE on those diseases were discussed and summarized, questions about its genetoxicity and hepatotoxicity were also discussed during its safety study to make the foundation for long-term medication and clinical research in the near future.