X-ray volumetric imaging in image-guided radiotherapy: The new standard in on-treatment imaging
X-ray volumetric imaging in image-guided radiotherapy: The new standard in on-treatment imaging
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DOI：
10.1016/j.ijrobp.2005.09.018
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发表时间：
2006-02-01
影响因子：
7
通讯作者：
Price, P
中科院分区：
文献类型：
--
作者：
McBain, CA;Henry, AM;Price, P
目的：X射线体积成像(XVI)首次实现了三维(3D)千伏锥束计算机体层摄影(CT)图像的在线采集。2003年7月开始使用Synergy系统(Elekta，Crawley，UK)进行临床成像。这项研究评估了图像质量和提供的剂量，并评估了在一系列解剖位置进行治疗验证的临床实用性。方法和材料：30例患者在10个不同的解剖位置接受放射治疗。患者在他们的设置位置进行成像。使用皮肤表面的热释光密度测量接收到的辐射剂量。由有经验的临床医生对XVI在验证靶区体积覆盖方面的应用进行定性评估。结果：在所有解剖部位的治疗位置均完成了X射线体积成像的采集。在不可能进行完全门架旋转的地方，从部分旋转获得的投影图像重建XVI。器官边界的软组织定义允许直接评估所有部位的3D靶区覆盖范围。个人图像质量取决于成像参数和患者特征。放射剂量范围从头部的0.003~0.03Gy.结论：治疗中的XVI在可接受的低剂量下为所有解剖部位提供了软组织清晰度的3D验证图像。这项技术为治疗验证设定了新的标准，并将促进新的适应性放射治疗技术的发展。(C)2006年爱思唯尔公司。
Purpose: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites.Methods and Materials: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians.Results: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis.Conclusions: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques. (C) 2006 Elsevier Inc.