Therapeutic Angiogenesis With Autologous Hepatic Tissue Implantation and Omental Wrapping
Therapeutic Angiogenesis With Autologous Hepatic Tissue Implantation and Omental Wrapping
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DOI：
10.1253/circj.cj-08-0167
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Matsukawa, Mai
中科院分区：
文献类型：
--
作者：
Shao, Zhan-Qiang;Kawasuji, Michio;Matsukawa, Mai
背景肝脏产生各种血管生成和细胞保护性生长因子，大网膜具有促进伤口愈合的有效血管生成特性。在梗塞大鼠模型中研究肝组织植入加大网膜包裹诱导血管生成和恢复心功能的能力。方法和结果采用冠状动脉结扎法诱导大鼠心肌梗塞。包裹大网膜（大网膜固定术组），肝组织植入联合大网膜包裹（肝组织植入（H）组）或不采取其他治疗（对照组（C）组），4周后超声心动图评估心室功能。对梗死面积、心室重塑、血管密度和胶原密度进行形态测量和组织学评估。使用RT-PCR检查植入组织中血管生成生长因子的表达。 H组较厚（p
Background The liver produces various angiogenic and cytoprotective growth factors and the omentum has potent angiogenic properties that promote wound healing. The ability of hepatic tissue implantation plus omental wrapping to induce angiogenesis and restore cardiac function was investigated in a rat model of infarction.Methods and Results Myocardial infarction was induced in rats using coronary artery ligation. The omentum was wrapped (omentopexy group), hepatic tissue implantation was combined with omental wrapping (hepatic tissue implantation (H) group) or no other treatment was applied (control (C) group), and then ventricular function was evaluated by echocardiography 4 weeks later. Infarct size, ventricular remodeling, vascular density and collagen density were morphometrically and histologically evaluated. The expression of angiogenic growth factors in implanted tissues was examined using RT-PCR. The H group had thicker (p