Cancer incidence in the south Asian population of California, 1988-2000.
Cancer incidence in the south Asian population of California, 1988-2000.
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DOI：
10.1186/1477-3163-4-21
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发表时间：
2005-11-10
影响因子：
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通讯作者：
Parikh-Patel, Arti
中科院分区：
文献类型：
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作者：
Jain, Ratnali V;Mills, Paul K;Parikh-Patel, Arti
虽然南亚人（SA）占美国亚裔人口的绝大多数，对这些移民人口中的癌症知之甚少。南亚人主要来自印度、巴基斯坦、孟加拉国和斯里兰卡。我们计算了1988-2000年间加州（SA最集中的州）SA人群中癌症的年龄校正发病率和时间趋势，并将这些发病率与本地亚裔印度人以及加州的亚裔/太平洋岛民（API）和白色非西班牙裔人群（NHW）的发病率进行了比较。计算了1988-2000年期间在加州SA人群中观察到的年龄校正发病率。为了正确识别癌症病例的种族，使用“Nam Pehchan”（英国开发的软件）来识别来自加州基于人群的癌症登记处（CCR）的SA起源的分子病例。分母来自美国人口普查局。计算SA的发生率，并进行时间趋势分析。还从CCR获得了API和加州NHW人群的比较数据，并使用Globocan 2002的发病率确定印度的发病率。在1988-2000年间，加州的SA诊断出5192例癌症。与本地亚裔印度人相比，加州SA中除口咽癌、食管癌和宫颈癌外的所有部位的癌症发病率均较高。与加州的API相比，SA人群发生更多的食管癌、胆囊癌、前列腺癌、乳腺癌、卵巢癌和子宫癌，以及淋巴瘤、白血病和多发性骨髓瘤。与加州的NHW人群相比，SA人群发生胃癌、肝癌、胆管癌、胆囊癌、宫颈癌和多发性骨髓瘤的比例更高。结肠癌和乳腺癌的发病率呈明显的时间趋势。加州的SA人群经历了独特的癌症发病模式，最有可能与文化适应、筛查和烟草习惯相关。需要对SA中的主要癌症进行早期诊断。如果不采取必要的措施来遏制乳腺癌、结肠癌和肺癌的增长，南加州的发病率很快就会接近加州的NHW人口。
Although South Asians (SA) form a large majority of the Asian population of U.S., very little is known about cancer in this immigrant population. SAs comprise people having origins mainly in India, Pakistan, Bangladesh and Sri Lanka. We calculated age-adjusted incidence and time trends of cancer in the SA population of California (state with the largest concentration of SAs) between 1988–2000 and compared these rates to rates in native Asian Indians as well as to those experienced by the Asian/Pacific Islander (API) and White, non-Hispanic population (NHW) population of California. Age adjusted incidence rates observed among the SA population of California during the time period 1988–2000 were calculated. To correctly identify the ethnicity of cancer cases, 'Nam Pehchan' (British developed software) was used to identify numerator cases of SA origin from the population-based cancer registry in California (CCR). Denominators were obtained from the U.S. Census Bureau. Incidence rates in SAs were calculated and a time trend analysis was also performed. Comparison data on the API and the NHW population of California were also obtained from CCR and rates from Globocan 2002 were used to determine rates in India. Between 1988–2000, 5192 cancers were diagnosed in SAs of California. Compared to rates in native Asian Indians, rates of cancer in SAs in California were higher for all sites except oropharyngeal, oesophageal and cervical cancers. Compared to APIs of California, SA population experienced more cancers of oesophagus, gall bladder, prostate, breast, ovary and uterus, as well as lymphomas, leukemias and multiple myelomas. Compared to NHW population of California, SAs experienced more cancers of the stomach, liver and bile duct, gall bladder, cervix and multiple myelomas. Significantly increasing time trends were observed in colon and breast cancer incidence. SA population of California experiences unique patterns of cancer incidence most likely associated with acculturation, screening and tobacco habits. There is need for early diagnosis of leading cancers in SA. If necessary steps are not taken to curb the growth of breast, colon and lung cancer, rates in SA will soon approximate those of the NHW population of California.