Micromanagement of Drosophila Post-Embryonic Development by Hox Genes.
Micromanagement of Drosophila Post-Embryonic Development by Hox Genes.
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DOI：
10.3390/jdb10010013
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发表时间：
2022-02-18
影响因子：
2.7
通讯作者：
McGregor AP
中科院分区：
文献类型：
--
作者：
Buffry AD;McGregor AP
Hox基因在发育早期起作用，以确定动物的区域身份。因此，Hox基因表达的丧失或获得可以改变这种身份并引起同源异型转化。20多年前，人们观察到Hox基因在动物身体计划模式中的作用涉及发育过程中细胞命运和身份的精细调节，扮演着Michael Akam在关键观点论文中提出的“微观管理者”的角色。因此，除了指定动物身体上结构的发育位置外，Hox基因还可以帮助精确塑造它们的形态。在这里，我们回顾的工作，提供了重要的见解Hox基因在影响细胞命运的作用，在果蝇胚胎发育后，以调节精细尺度的图案和形态。我们还探讨了这是如何通过Hox基因，特定的辅助因子及其数百个靶基因的复杂调控来实现的。我们认为，进一步研究Hox基因在果蝇胚胎后发育中的调控和作用，对于更普遍地理解基因调控、细胞命运和表型分化具有巨大的潜力。
Hox genes function early in development to determine regional identity in animals. Consequently, the loss or gain of Hox gene expression can change this identity and cause homeotic transformations. Over 20 years ago, it was observed that the role of Hox genes in patterning animal body plans involves the fine-scale regulation of cell fate and identity during development, playing the role of ‘micromanagers’ as proposed by Michael Akam in key perspective papers. Therefore, as well as specifying where structures develop on animal bodies, Hox genes can help to precisely sculpt their morphology. Here, we review work that has provided important insights about the roles of Hox genes in influencing cell fate during post-embryonic development in Drosophila to regulate fine-scale patterning and morphology. We also explore how this is achieved through the regulation of Hox genes, specific co-factors and their complex regulation of hundreds of target genes. We argue that further investigating the regulation and roles of Hox genes in Drosophila post-embryonic development has great potential for understanding gene regulation, cell fate and phenotypic differentiation more generally.