Menstrual Cycle Irregularity in Adolescence Is Associated With Cardiometabolic Health in Early Adulthood.
Menstrual Cycle Irregularity in Adolescence Is Associated With Cardiometabolic Health in Early Adulthood.
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DOI：
10.1161/jaha.123.029372
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发表时间：
2023-09-19
影响因子：
5.4
通讯作者：
Polonsky, Tamar S.
中科院分区：
文献类型：
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作者：
Keenan, Kate;Hipwell, Alison E.;Polonsky, Tamar S.
月经周期不规律与心血管和心脏代谢疾病有关。我们在匹兹堡女孩研究的子样本中测试了初潮年龄和青春期周期不规律与成年早期心脏代谢健康之间的关联。年度访谈数据用于评估 15 岁时初潮年龄和周期不规则性（即大于或小于每 27-29 天一次）。在匹兹堡女孩研究的子样本（n=352；68.2% 黑人）中测量了 22 至 25 岁的心脏代谢健康状况，包括血压、腰围、空腹血清胰岛素、血糖和血脂。 T 检验用于连续数据和二分数据的比值比，以比较心脏代谢健康状况随月经开始和规律性变化的差异。初潮早（即11岁之前；n=52）与腰围相关（P=0.043）。报告青春期周期不规则的参与者 (n=50) 的胰岛素、葡萄糖和甘油三酯水平显着较高，收缩压和舒张压也较高（P 值范围为 0.035 至 0.005），并且与报告周期规律的女性相比，在成年早期更有可能出现心脏代谢前期疾病的临床指标（比值比范围为 1.89 至 2.56）。女性（尤其是黑人女性）心血管和代谢疾病的发病率不断上升且发病较早，凸显了尽早确定可靠风险指数的必要性。月经周期不规律可能有助于这一目的，并有助于阐明女性生殖健康在保护和增加以后心血管和心脏代谢疾病风险方面的作用。
Menstrual cycle irregularities are associated with cardiovascular and cardiometabolic disease. We tested associations between age at menarche and cycle irregularity in adolescence and cardiometabolic health in early adulthood in a subsample from the Pittsburgh Girls Study. Data from annual interviews were used to assess age at menarche and cycle irregularity (ie, greater or less than every 27–29 days) at age 15 years. At ages 22 to 25 years, cardiometabolic health was measured in a subsample of the Pittsburgh Girls Study (n=352; 68.2% Black), including blood pressure, waist circumference, and fasting serum insulin, glucose, and lipids. T tests were used for continuous data and odds ratios for dichotomous data to compare differences in cardiometabolic health as a function of onset and regularity of menses. Early menarche (ie, before age 11 years; n=52) was associated with waist circumference (P=0.043). Participants reporting irregular cycles (n=50) in adolescence had significantly higher levels of insulin, glucose, and triglycerides, and higher systolic and diastolic blood pressure (P values range from 0.035 to 0.005) and were more likely to have clinical indicators of cardiometabolic predisease in early adulthood compared with women who reported regular cycles (odds ratios ranged from 1.89 to 2.56). Increasing rates and earlier onset of cardiovascular and metabolic disease among women, especially among Black women, highlights the need for identifying early and reliable risk indices. Menstrual cycle irregularity may serve this purpose and help elucidate the role of women's reproductive health in protecting and conferring risk for later cardiovascular and cardiometabolic diseases.