Nitric oxide and vascular reactivity in sepsis
Nitric oxide and vascular reactivity in sepsis
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DOI：
10.1097/shk.0b013e3181818518
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发表时间：
2008-01-01
期刊：
影响因子：
3.1
通讯作者：
Assreuy, Jamil
中科院分区：
文献类型：
--
作者：
Fernandes, Daniel;Assreuy, Jamil
Sepsis and septic shock are major causes of morbidity and mortality in critically ill patients. Sepsis and septic shock induce a profound fall in the peripheral vascular tone. NO has been implicated as a key player in vascular changes of sepsis and septic shock. In this brief review, two points are focused in greater detail: first, the involvement of guanylate cyclase and potassium channels in NO vascular effects in sepsis; second, the role played by NO and its two effectors in the long-lasting modifications of vascular reactivity in sepsis. Some recent developments in the area are reviewed.
