Factors associated with hospital admission for exacerbation of chronic obstructive pulmonary disease
Factors associated with hospital admission for exacerbation of chronic obstructive pulmonary disease
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DOI：
10.1016/j.arbres.2011.10.009
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发表时间：
2012-03-01
影响因子：
8
通讯作者：
Miravitlles, Marc
中科院分区：
文献类型：
--
作者：
Alcazar, Bernardino;Garcia-Polo, Cayo;Miravitlles, Marc
简介：慢性阻塞性肺疾病（COPD）的急性加重需要住院治疗，对疾病的进展产生重大影响，并产生高额的医疗costs.Method：一项多中心，横断面，观察性研究，目的是确定与COPD患者住院相关的因素。我们获得了社会人口学和人体测量学特征，生活质量，呼吸系统症状，焦虑和抑郁，体力活动和肺功能测试的数据。我们分析了他们与入院的多因素分析，使用logistic回归model.Results：我们分析了127例患者，其中50人（39%）已住院。93.7%为男性，平均年龄67岁（SD = 9），FEV1为41.9%（SD = 15.3）。在获得的第一个模型中，基线SpO2、BODE指数和急诊室（ER）访视与入院相关，ROC曲线下面积（AUC）为0.809。在第二个模型中，我们只包括了容易获得的变量（不包括6分钟步行试验），只有SpO2和既往ER访视具有显著性，AUC ROC为0.783。结论：COPD急性加重住院与SpO2较差、BODE指数评分较高和ER访视次数较多相关。如果你没有6分钟步行测试，其他两个变量提供了类似的区分能力。(c)2011年SEPAR。出版社：Elsevier Espana，S.L. All rights reserved.
Introduction: Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) that require hospital admission have a major impact on the progression of disease and generate high health costs.Method: A multi-center, cross-sectional, observational, study was conducted with the aim to identify factors associated with hospital admission in patients with COPD. We obtained data of socio-demographic and anthropometric characteristics, quality of life, respiratory symptoms, anxiety and depression, physical activity and pulmonary function tests. We analyzed their association with hospital admission with a multivariate analysis using a logistic regression model.Results: We analyzed 127 patients, 50 (39%) of whom had been hospitalized. 93.7% were men, mean age 67 years (SD = 9) and a FEV1 of 41.9% (SD = 15.3). In the first model obtained, the baseline SpO2, the BODE index and emergency room (ER) visits were associated with hospital admission and the area under the ROC curve (AUC) was 0.809. In a second model we included only variables readily available (without the 6 minutes walking test) and only the SpO2 and previous visits to the ER weresignificant with an AUC ROC 0.783.Conclusions: hospital admission for exacerbation of COPD is associated with poor SpO2, higher BODE index score and a greater number of visits to the ER. In case you do not have the 6 minutes walking test, the other two variables offer a similar discriminative ability. (c) 2011 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.