Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia.: A PET study
Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia.: A PET study
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DOI：
10.1016/j.neurobiolaging.2003.10.007
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发表时间：
2004-09-01
影响因子：
4.2
通讯作者：
Kurz, A
中科院分区：
文献类型：
--
作者：
Diehl, J;Grimmer, T;Kurz, A
目的：研究额颞叶痴呆(FTD)和语义性痴呆(SD)患者的脑葡萄糖代谢模式。方法：对25例轻度FTD和9例轻度SD患者及15例年龄匹配的健康对照组进行18F-FDG正电子发射断层扫描。结果：与健康对照组相比，FTD患者额叶代谢明显降低(身高阈值P<；0.001)，运动皮质无明显改变。SD患者在整个左侧颞叶和右侧颞叶均表现为低代谢。结论：在FFD和SID的临床症状中，存在两种不同的脑代谢模式。FTD与额叶代谢低下有关，而在SD患者中，大脑葡萄糖代谢仅在颞叶减少。我们的发现与以下观点是一致的，即FTD和SD始于严格意义上的脑叶神经元退变，直到更晚期才能看到病变的扩散。(C)2003 Elsevier Inc.保留所有权利。
Objective: To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD).Methods: 25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG-positron emission tomography. Patient scans were compared with control scans using SPM-99.Results: As compared with healthy control subjects patients with FTD showed an extensive symmetrical hypometabolism of the frontal lobes (height threshold P < 0.001) which spared the motor cortex. Patients with SD showed a hypometabolism in the whole left temporal lobe and in the right temporal pole.Conclusions: In the clinical syndromes of FFD and SID two distinct patterns of cerebral metabolism were identified. FTD was associated with frontal hypometabolism, whereas in SD cerebral glucose metabolism was exclusively reduced in the temporal lobes. Our findings are consistent with the notion that FTD and SD begin as strictly lobar neuronal degenerations and that a spread of pathological changes is not seen until more advanced stages. (C) 2003 Elsevier Inc. All rights reserved.